Discrete Event Simulation Applied to Pediatric Phase I Oncology Designs

被引：10
|
作者：
Barrett, J. S. [1 ,2 ]
Skolnik, J. M. [1 ,2 ]
Jayaraman, B. [1 ,2 ]
Patel, D. [1 ,2 ]
Adamson, P. C. [1 ,2 ]
机构：
[1] Childrens Hosp Philadelphia, Div Clin Pharmacol & Therapeut, Lab Appl Pharmacokinet & Pharmacodynam, Philadelphia, PA 19104 USA
[2] Univ Penn, Sch Med, Dept Pediat, Philadelphia, PA 19104 USA
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS | 2008年 / 84卷 / 06期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/clpt.2008.193
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Little attention has been paid to the study of trial efficiency despite increasing pressures to conduct clinical research in an expedient manner and the ever-present "time is money" mantra that governs the pharmaceutical research concerned with drug development. Still less appreciated is the impact that trial inefficiency can have when studies compete for a finite study population desperate to test potentially lifesaving new medicines. We have used discrete event simulation techniques to examine such sensitivities in pediatric oncology.
引用
收藏
页码：729 / 733
页数：5
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