A general Bronsted acid-catalyzed allylation of benzhydryl alcohols

被引：12
|
作者：
Orizu, Ifedi [1 ]
Solshan, Yuri [2 ]
机构：
[1] Univ Arkansas, 345 N Campus Dr, Fayetteville, AR 72701 USA
[2] UOIT, 2000 Simcoe St North, Oshawa, ON L1H 7K4, Canada
来源：
TETRAHEDRON LETTERS | 2016年 / 57卷 / 51期
基金：
加拿大自然科学与工程研究理事会;
关键词：
Bronsted acid; Allylation; Benzhydryl alcohol; Catalysis; Metal-free; NUCLEOPHILIC-SUBSTITUTION; PROPARGYLIC ALCOHOLS; BENZYLIC ALCOHOLS; COUPLING REACTIONS; LEWIS-ACID; ALLYLTRIMETHYLSILANE; ALLYLSILANES; ETHERS; ALKYLATION; EFFICIENT;
D O I：
10.1016/j.tetlet.2016.11.044
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Efficient Bronsted acid-catalyzed allylation of benzhydryl alcohols has been developed. The reaction occurs within 5 min in the presence of sub-stoichiometric amounts of HBF4 center dot OEt2 to afford the desired products in good to excellent yields. A variety of functional groups were tolerated under the developed conditions including amides, aldehydes, hydroxyl and carboxylic acid. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5798 / 5800
页数：3
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