Characterization and enhanced antioxidant activity of the inclusion complexes of baicalin with p-sulfonatocalix[n]arenes

被引：5
|
作者：
Chao, Jianbin [1 ]
Wang, Xiaolu [1 ,2 ]
Xu, Miao [1 ,2 ]
Zuo, Ying [3 ]
机构：
[1] Shanxi Univ, Res Inst Appl Chem, Taiyuan 030006, Shanxi, Peoples R China
[2] Shanxi Univ, Sch Chem & Chem Engn, Taiyuan 030006, Shanxi, Peoples R China
[3] Shanxi Univ, Sci Instrument Ctr, Taiyuan 030006, Shanxi, Peoples R China
来源：
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY | 2019年 / 93卷 / 3-4期
基金：
中国国家自然科学基金;
关键词：
Baicalin; p-Sulfonatocalix[n]arenes; Antioxidant activity; Stability; SCUTELLARIAE-RADIX; BINDING BEHAVIORS; CALIXARENES; SULFONATOCALIXARENES; CYCLODEXTRINS; COMPONENTS; MOLECULES; ACID;
D O I：
10.1007/s10847-019-00887-w
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Baicalin, one of the main active constituents of the isolated root of Scutellaria baicalensis. It has many health-promoting properties. However, it is easy to be oxidized that impedes its application in the practical life. In this study, the inclusion complexes of baicalin with p-sulfonatocalix[n]arenes were studied by fluorescence spectroscopy, ultraviolet-visible spectroscopy (UV-vis), fourier transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, and atomic force microscopy. The results showed that baicalin was able to form inclusion complexes with p-sulfonatocalix[n]arenes in a molar ratio of 1:1 and the association constants (K) were different at different pH. Meanwhile, the antioxidant ability and stability experiments of baicalin and the inclusion complexes were done. The experimental results indicated that both the stability and the antioxidant activity of baicalin significantly increased by the formation of inclusion complexes with p-sulfonatocalix[n]arenes.
引用
收藏
页码：361 / 370
页数：10
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