Association of IL-10 (-819T/C,-592A/C and-1082A/G) and IL-6-174G/C gene polymorphism and the risk of pneumonia-induced sepsis

被引：1

作者：

Mao, Zheng-Rong ^{[1
]}

Zhang, Shao-Lei ^{[1
]}

Feng, Bo ^{[1
]}

机构：

[1] Henan Univ Tradit Chinese Med, Dept Intens Care Unit, Affiliated Hosp 1, 19 Renmin Rd, Zhengzhou 450000, Peoples R China

来源：

BIOMARKERS | 2017年 / 22卷 / 02期

关键词：

Single-nuclear polymorphism; sepsis; inflammation; IL-10; IL-6; mRNA; CHINESE HAN POPULATION; PROMOTER POLYMORPHISMS; SEPTIC SHOCK; INTERLEUKIN-10; POLYMORPHISMS; PLASMA INTERLEUKIN-6; DEFINITIONS; BIOMARKERS; GUIDELINES; RELEVANCE; DIAGNOSIS;

D O I：

10.1080/1354750X.2016.1210677

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Context: Association between inherited variants and the risks of sepsis is controversial. Objective: To evaluate the risk of pneumonia-induced sepsis by examining its linkage with polymorphisms of IL-6 and IL-10. Materials and methods: Samples were obtained from 188 pneumonia-induced sepsis patients, 162 pneumonia patients and 200 healthy controls. Results: Subjects with IL-10 -1082 AA genotypes and IL-6 -174 CC genotype had a higher risk of sepsis and increased mRNA levels. Conclusion: The variants of IL-10 -1082 A allele and IL-6 -174 C allele contributed to an increased risk of pneumonia-induced sepsis.

引用

页码：106 / 112

页数：7

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