Clinical Applications of the Photopic Negative Response to Optic Nerve and Retinal Diseases

被引：61
|
作者：
Machida, Shigeki [1 ]
机构：
[1] Iwate Med Univ, Dept Ophthalmol, Sch Med, Morioka, Iwate 0208505, Japan
来源：
JOURNAL OF OPHTHALMOLOGY | 2012年 / 2012卷
关键词：
FLASH ELECTRORETINOGRAM; FULL-FIELD; OSCILLATORY POTENTIALS; GANGLION-CELLS; HUMAN ERG; PHNR; REDUCTION; THICKNESS; AMACRINE; BLOCKADE;
D O I：
10.1155/2012/397178
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
The photopic negative response (PhNR) in response to a brief flash is a negative-going wave following the b-wave of the cone electroretinogram (ERG) that is driven by retinal ganglion cells (RGCs). The function of RGCs is objectively evaluated by analysing the PhNR. We reviewed articles regarding clinical use of the PhNR. The PhNR was well correlated with the visual sensitivity obtained by standard automated perimetry and morphometric parameters of the inner retina and optic nerve head in optic nerve and retinal diseases. Moreover, combining the PhNR with focal or multifocal ERG techniques enables the objective assessment of local function of RGCs. The PhNR is therefore likely to become established as an objective functional test for optic nerve and retinal diseases involving RGC injury.
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页数：11
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