Next Generation AAV Vectors for Limiting Systemic Leakage and Improving Safety Following CNS Administration

被引：0
|
作者：
Murlidharan, Giridhar [1 ,2 ]
Rao, Lavanya [2 ]
Wang, Dan [3 ]
Corriher, Travis [2 ]
Seok-Oh, Kyung [2 ]
Gao, Guangping [3 ]
Samulski, R. Jude [2 ]
Tarantal, Alice F. [4 ]
Asokan, Aravind [1 ,2 ]
机构：
[1] Univ N Carolina, Dept Genet, Chapel Hill, NC USA
[2] Univ N Carolina, Gene Therapy Ctr, Chapel Hill, NC USA
[3] Univ Massachusetts, Sch Med, Gene Therapy Ctr, Worcester, MA USA
[4] Univ Calif Davis, Calif Natl Primate Res Ctr, Davis, CA 95616 USA
来源：
MOLECULAR THERAPY | 2015年 / 23卷
关键词：
D O I：
10.1016/S1525-0016(16)33618-8
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
14
引用
收藏
页码：S6 / S6
页数：1
相关论文
共 50 条
  • [1] Going Viral: The Next Generation of AAV Vectors
    Lemieux, Julianna
    [J]. Genetic Engineering and Biotechnology News, 2019, 39 (09): : 22 - 26
  • [2] Engineering Recombinant AAV Vectors for More Efficient and Restricted Gene Expression in the CNS after Systemic Administration
    Deverman, Benjamin E.
    Simpson, Bryan
    Pravdo, Piers
    Banerjee, Abhik
    Patterson, Paul H.
    [J]. MOLECULAR THERAPY, 2014, 22 : S118 - S118
  • [3] β-hexosaminidase lentiviral vectors:: transfer into the CNS via systemic administration
    Kyrkanides, S
    Miller, JH
    Brouxhon, SM
    Olschowka, JA
    Federoff, HJ
    [J]. MOLECULAR BRAIN RESEARCH, 2005, 133 (02): : 286 - 298
  • [4] Improving cell and gene therapy safety and performance using next-generation Nanoplasmid vectors
    Williams, James A.
    Paez, Patrick A.
    [J]. MOLECULAR THERAPY-NUCLEIC ACIDS, 2023, 32 : 494 - 503
  • [5] Lymphatic Transport Mediates Systemic Leakage of Peripherally Administered AAV9 Vectors
    Rivera, Ruth M. Castellanos
    Rao, Lavanya
    Murlidharan, Giridhar
    Corriher, Travis
    Asokan, Aravind
    [J]. MOLECULAR THERAPY, 2015, 23 : S77 - S77
  • [6] Positron Emission Tomography I-124-Labeled AAV Assessment of CSF to Blood Diffusion and Consequent Systemic Distribution of AAV Capsids Following CSF Administration of AAV Vectors
    Rosenberg, Jonathan B.
    Ballon, Douglas J.
    Kelly, James
    Fung, Edward
    De, Bishnu P.
    Kaminsky, Stephen M.
    Babich, John
    Hinderer, Christian
    Hordeaux, Juliette
    Wilson, James M.
    Crystal, Ronald G.
    [J]. MOLECULAR THERAPY, 2022, 30 (04) : 209 - 209
  • [7] Beta-hexosaminidase lentiviral vectors: transfer into the CNS via systemic administration
    Kyrkanides, S
    [J]. JOURNAL OF NEUROCHEMISTRY, 2004, 90 : 54 - 54
  • [8] Selection of Next Generation AAV Gene Therapy Vectors for Specific and Precise Gene Delivery
    Muench, Robert
    Kay, Mark
    [J]. MOLECULAR THERAPY, 2016, 24 : S101 - S101
  • [9] Development of CNS tropic AAV1-like variants with reduced liver-targeting following systemic administration in mice
    Drouyer, Matthieu
    Merjane, Jessica
    Nazareth, Deborah
    Knight, Maddison
    Scott, Suzanne
    Liao, Sophia H. Y.
    Ginn, Samantha L.
    Zhu, Erhua
    Alexander, Ian E.
    Lisowski, Leszek
    [J]. MOLECULAR THERAPY, 2024, 32 (03) : 818 - 836
  • [10] Next-generation AAV vectors for clinical use: an ever-accelerating race
    Weinmann, Jonas
    Grimm, Dirk
    [J]. VIRUS GENES, 2017, 53 (05) : 707 - 713
12345