Role of venlafaxine in prevention of cyclophosphamide-induced lung toxicity and airway hyperactivity in rats

Cydophosphamide (CP) is a drug used in chemotherapy and management of neoplastic diseases. This study aimed to investigate the prophylactic impacts of venlafaxine against CP-induced lung toxicity in rats. Rats were assigned randomly into 3 groups; control, CP (150 mg/kg) and CP/venlafaxine (50 mg/kg). On the end day, rats were sacrificed then bronchoalveolar fluid (BALF) and lungs were harvested. CP produced significant decrease in animal body weights and significant increase in lung/body weight ratio; levels of LDH, total protein, total and differential cell counts in BALF in comparison with control group. Moreover, significant elevation incontents of MDA, NOx, TNF-alpha and IL-1 beta and significant decline in GSH, SOD activities were observed in lung tissues. CP increased the response of tracheal zigzag to ACh. Histopathological results showed that CP increased inflammation and fibrosis in lung tissues. Venlafaxine restored most parameters to the normal levels. This protective effect of venlafaxine could be linked to its ability to reduce oxidative stress and inflammation.