EFFICACY OF AQUEOUS LEAF EXTRACT OF ANNONA MURICATA ON CYPERMETHRIN INDUCED HEPTOTOXICITY IN RATS

This study aims to elicit the potential efficacy of aqueous extract of Annona muricota leaf on induction of cadmium chloride on liver of rats, and compare with usage of Methotrexate, a known drug. Six groups of rats were maintained, one as control given saline, next given Cypermethrin (CYP) (0.05ml/100gm,BW/week), third given aqueous extract of Annona muricata leaf (AMLE) (0.05ml/100gm BW/week), fourth given both CYP and AMLE, fifth given methotrexate (MTX) (1.0mg/100gm BW/week) and sixth given CYP and MTX, for a duration of 60 days. After collection of blood for estimation of liver enzymes, liver tissues were collected and used for histo pathological studies. An increase in body weight and a decrease in liver weight seen in all the treatment groups, except MTX treated group. The activities of SGOT, SGPT, and ALP were significantly increased in all the treatment groups, except MTX supplemented group. Hepatoarchitecture is deranged on CYP treatment and partial reversal observed on AMLE supplementation; while near normal reversal can be observed on MTX supplementation.