Lesion volume and clinical outcome in stereotactic pallidotomy and thalamotomy

被引:9
|
作者
Goodman, SH
Wilkinson, S
Overman, J
Koller, WC
Tröster, A
Pahwa, R
Lyons, K
Kieltyka, J
Burns, J
Gordon, M
机构
[1] Univ Kansas, Med Ctr, Imaging Resource Ctr, Kansas City, KS 66103 USA
[2] Univ Kansas, Med Ctr, Dept Surg, Div Neurosurg, Kansas City, KS 66103 USA
[3] Univ Kansas, Med Ctr, Dept Neurol, Kansas City, KS 66103 USA
[4] Univ Kansas, Med Ctr, Dept Pharmacol Toxicol & Therapeut, Kansas City, KS 66103 USA
关键词
pallidotomy; thalamotomy; Parkinson's disease; essential tremor; magnetic resonance imaging;
D O I
10.1159/000029660
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Postoperative lesion volume and clinical outcome were assessed in 19 Parkinson's disease (PD) patients who received posteroventral pallidotomy, and in 14 essential tremor (ET) patients who received ventrolateral thalamotomy. Before and after surgery, PD patients were evaluated using the Unified PD Rating Scale (UPDRS), and ET patients were evaluated using the Fahn-Tolosa-Marin (FTM) tremor rating scale. Inner and total lesion volumes were determined with postoperative MR imaging and three-dimensional data segmentation. Lesion volumes were compared to percent improvement in UPDRS and FTM scores, using Spearman's rank-order correlation test. No rank-order correlations were found between lesion volume and clinical improvement in either the PD or the ET patients. In performing stereotactic surgery for movement disorders, any lesion volume within a prescribed range may be equally effective in relieving symptoms associated with PD or ET.
引用
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页码:164 / 172
页数:9
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