A novel domino strategy for forming poly-substituted quaternary imidazoles through a Cs2CO3-promoted aryl migration process

被引：7
|
作者：
Xu, Hai-Wei [1 ]
Fan, Wei
Li, Meng-Yuan
Jiang, Bo
Wang, Shu-Liang
Tu, Shu-Jiang
机构：
[1] Jiangsu Normal Univ, Sch Chem & Chem Engn, Xuzhou 211116, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2013年 / 11卷 / 22期
基金：
美国国家科学基金会;
关键词：
DARZENS CONDENSATION REACTION; STEREOSELECTIVE-SYNTHESIS; ALKALOIDS; STEREOCENTERS; HYDANTOCIDIN;
D O I：
10.1039/c3ob40666k
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new domino strategy for the synthesis of highly functionalized quaternary imidazole derivatives via [3 + 2] heterocyclization, involving aryl migration and ring-opening of oxirane, has been developed. This domino reaction enables the successful assembly of three new sigma bonds including two C-N bonds in a simple operation. Features of this strategy include the mild conditions, convenient operation, and short reaction periods (15-20 min).
引用
收藏
页码：3603 / 3607
页数：5
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