Interaction of Human Amylin with Phosphatidylcholine and Phosphatidylserine Membranes

被引：3
|
作者：
Sciacca, Michele Francesco Maria [1 ]
Carbone, Vincenzo [1 ]
Pappalardo, Matteo [1 ]
Milardi, Danilo [2 ]
La Rosa, Carmelo [1 ]
Grasso, Domenico Maria [1 ]
机构：
[1] Univ Catania, Dipartimento Sci Chim, I-95125 Catania, Italy
[2] Ist CNR Biostrutture & Bioimmagini, Sez Catania, Catania, Italy
来源：
MOLECULAR CRYSTALS AND LIQUID CRYSTALS | 2009年 / 500卷
关键词：
amylin; circular dicroism; differential scanning calorimetry; lipid bilayer; molecular modeling; ISLET-AMYLOID POLYPEPTIDE; DIABETES-MELLITUS; PROTEIN; PEPTIDE; LANGERHANS; MECHANISM; VESICLES; FIBRILS; CELLS; MODEL;
D O I：
10.1080/15421400802713710
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We studied the interaction of human amylin with dipalmitoylphosphatidylcholine and dipalmitoylphosphatidylserine vesicles using differential scanning calorimetry, circular dichroism and molecular modelling. The results suggest that inappropriate insertion of amylin into the hydrophobic core of a lipid bilayer could hinder the secretion of amylin from pancreatic beta-cells.
引用
收藏
页码：73 / 81
页数：9
相关论文
共 50 条
  • [1] The Interaction of Melittin with Dimyristoyl Phosphatidylcholine-Dimyristoyl Phosphatidylserine Lipid Bilayer Membranes
    Rai, Durgesh K.
    Qian, Shuo
    Heller, William T.
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2016, 1858 (11): : 2788 - 2794
  • [2] Binding of calcium to phosphatidylcholine-phosphatidylserine membranes
    Sinn, Cornelia G.
    Antonietti, Markus
    Dimova, Rurniana
    [J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2006, 282 : 410 - 419
  • [3] INTERACTION ENERGIES OF MIXING PHOSPHATIDYLSERINE AND PHOSPHATIDYLCHOLINE MONOLAYERS
    ALSINA, MA
    MESTRES, C
    VALENCIA, G
    ANTON, JMG
    REIG, F
    [J]. COLLOIDS AND SURFACES, 1988, 34 (02): : 151 - 158
  • [4] INTERACTION OF COLCHICINE WITH PHOSPHATIDYLCHOLINE MEMBRANES
    ALTSTIEL, LD
    LANDSBERGER, FR
    [J]. NATURE, 1977, 269 (5623) : 70 - 72
  • [5] Interaction of amylin species with transition metals and membranes
    Alghrably, Mawadda
    Czaban, Iwona
    Jaremko, Lukasz
    Jaremko, Mariusz
    [J]. JOURNAL OF INORGANIC BIOCHEMISTRY, 2019, 191 : 69 - 76
  • [6] CALCIUM-INDUCED PHASE SEPARATIONS IN PHOSPHATIDYLSERINE-PHOSPHATIDYLCHOLINE MEMBRANES
    OHNISHI, S
    ITO, T
    [J]. BIOCHEMISTRY, 1974, 13 (05) : 881 - 887
  • [7] Lipid Flip-Flop in Binary Membranes Composed of Phosphatidylserine and Phosphatidylcholine
    Brown, Krystal L.
    Conboy, John C.
    [J]. JOURNAL OF PHYSICAL CHEMISTRY B, 2013, 117 (48): : 15041 - 15050
  • [8] Deciphering Lipid Arrangement in Phosphatidylserine/Phosphatidylcholine Mixed Membranes: Simulations and Experiments
    Zak, Agata
    Korshunova, Ksenia
    Rajtar, Natan
    Kulig, Waldemar
    Kepczynski, Mariusz
    [J]. LANGMUIR, 2023, 39 (51) : 18995 - 19007
  • [9] PROTON-INDUCED PHASE-SEPARATION IN PHOSPHATIDYLSERINE-PHOSPHATIDYLCHOLINE MEMBRANES
    TOKUTOMI, S
    OHKI, K
    OHNISHI, SI
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1980, 596 (02) : 192 - 200
  • [10] PROMOTION OF BETA-STRUCTURE BY INTERACTION OF DIABETES ASSOCIATED POLYPEPTIDE (AMYLIN) WITH PHOSPHATIDYLCHOLINE
    MCLEAN, LR
    BALASUBRAMANIAM, A
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1992, 1122 (03) : 317 - 320
12345