Role of receptor for advanced glycation end-products in pathogenesis of psoriasis

This review summarizes the existing knowledge regarding the role of receptor for advanced glycation end products in pathogenesis of psoriasis. This receptor plays a crucial role in the inflammatory response. By interacting with multiple ligands and activating several signaling mechanisms, receptor for advanced glycation end products regulates gene expression via a group of well-characterized transcription factors, such as NFkB and AP1. The expression of receptor for advanced glycation end products in both immune cells and their targets, a high stability of this receptor in complexes with ligands as well as a positive feedback loop, upregulating the expression of its certain ligands, suggest receptor for advanced glycation end products as a possible principal factor that promotes the development of psoriasis. Considering receptor for advanced glycation end products as a potential master regulator of several processes that play a crucial role in development of psoriatic plaques, we believe that further experimental studies are needed to elucidate how exactly this receptor converts a transient inflammatory reaction to a sustainable inflammatory response. These studies are also needed for the development of novel medications that target receptor for advanced glycation end products and signaling mechanisms that this receptor activates.