The shared epitope and severity of rheumatoid arthritis

被引：40
|
作者：
Gorman, JD [1 ]
Criswell, LA [1 ]
机构：
[1] Univ Calif San Francisco, Div Rheumatol, San Francisco, CA 94143 USA
来源：
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2002年 / 28卷 / 01期
关键词：
D O I：
10.1016/S0889-857X(03)00069-3
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The shared epitope (SE) hypothesis is discussed in relation to susceptibility to rheumatoid arthritis (RA), and to the development of more severe manifestations of the disease. Review of the these issues reveals a complex association between the SE and RA severity that is highly influenced by ethnic background, clinical factors, and the particular SE allele inherited. Determination of the precise relationship between the SE and RA severity may have important implications for future patient care and research.
引用
收藏
页码：59 / +
页数：21
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