The role of statins in cancer prevention and treatment

被引：0
|
作者：
Stamm, Jason A.
Ornstein, Deborah L.
机构：
[1] Univ Vermont, Coll Med, Hematol Oncol Unit, Fletcher Allen Hlth Care,Vermont Canc Ctr, Burlington, VT 05401 USA
[2] Wilford Hall USAF Med Ctr, San Antonio, TX 78236 USA
来源：
ONCOLOGY-NEW YORK | 2005年 / 19卷 / 06期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Statins inhibit the activity of the rate-limiting enzyme in the cholesterol biosynthetic pathway, HMG-CoA reductase, and are widely prescribed for lowering plasma lipid levels. Several statins have antitumor effects in experimental models, and observational studies suggest that this anticancer activity in the laboratory may translate into effective treatments and/or preventive strategies for certain human cancers. This paper reviews the laboratory and clinical evidence that statins have anticancer activity, discusses the possible mechanisms by which tumor growth may be inhibited by this class of drugs, and outlines strategies for the evaluation of these agents in the prevention and treatment of human cancers.
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收藏
页码：739 / 750
页数：12
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