Interference with acute nausea and anticipatory nausea in rats by fatty acid amide hydrolase (FAAH) inhibition through a PPARα and CB1 receptor mechanism, respectively: a double dissociation

被引:26
|
作者
Rock, Erin M. [1 ,2 ]
Limebeer, Cheryl L. [1 ,2 ]
Ward, Jordan M. [1 ,2 ]
Cohen, Arianne [1 ,2 ]
Grove, Katherine [1 ,2 ]
Niphakis, Micah J. [3 ,4 ]
Cravatt, Benjamin F. [3 ,4 ]
Parker, Linda A. [1 ,2 ]
机构
[1] Univ Guelph, Dept Psychol, Guelph, ON N1G 2W1, Canada
[2] Univ Guelph, Collaborat Neurosci Program, Guelph, ON N1G 2W1, Canada
[3] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
[4] Scripps Res Inst, Dept Physiol Chem, La Jolla, CA 92037 USA
基金
美国国家卫生研究院; 加拿大自然科学与工程研究理事会;
关键词
FAAH inhibition; Acute nausea; Anticipatory nausea; PF-3845; URB597; MK886; Rimonabant; PPAR alpha; CB1; CANNABINOID RECEPTOR; MONOACYLGLYCEROL LIPASE; PATIENT PERCEPTIONS; NUCLEAR RECEPTORS; TASTE AVOIDANCE; INVERSE AGONISM; SUNCUS-MURINUS; CHEMOTHERAPY; ACTIVATION; ANANDAMIDE;
D O I
10.1007/s00213-015-4050-7
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Fatty acid amide hydrolase (FAAH) inhibition elevates anandamide (AEA), which acts on cannabinoid (CB1 and CB2) receptors, as well as N-palmitoylethanolamide (PEA) and N-oleoylethanolamine (OEA), which act on peroxisome proliferator-activated receptor alpha (PPAR alpha). Here, we determine the mechanism of action of FAAH inhibition on acute and anticipatory nausea (AN). We compared the effectiveness and mechanism of action of two FAAH inhibitors, URB597 and PF-3845, to reduce acute nausea and AN in rodent models of conditioned gaping. For assessment of acute nausea, rats were pretreated with vehicle (VEH), URB597 (0.3 and 10 mg/kg, experiment 1a) or PF-3845 (10 mg/kg, experiment 1b) 120 min prior to a saccharin-lithium chloride (LiCl) pairing. To assess the CB1 receptor or PPAR alpha mediation of the effect of PF-3845 on acute nausea, rats were also pretreated with rimonabant or MK886, respectively. For assessment of AN, following four pairings of a novel context with LiCl, rats received a pretreatment of VEH, URB597 (0.3 mg/kg, experiment 2a), or PF-3845 (10, 20 mg/kg, experiment 2b) 120 min prior to placement in the AN context. To assess the CB1 receptor or PPAR alpha mediation of the effect, rats were also pretreated with rimonabant or MK886, respectively. PF-3845 (10 mg/kg, but not URB597 0.3 or 10 mg/kg) suppressed acute nausea via PPAR alpha, but not CB1 receptors. URB597 (0.3 and 10 mg/kg) or PF-3845 (10 and 20 mg/kg) reduced AN via CB1 receptors, but not PPAR alpha. FAAH inhibition reduces acute nausea and AN through PPAR alpha and CB1 receptor mediated effects, respectively.
引用
收藏
页码:3841 / 3848
页数:8
相关论文
共 35 条
  • [1] Interference with acute nausea and anticipatory nausea in rats by fatty acid amide hydrolase (FAAH) inhibition through a PPARα and CB1 receptor mechanism, respectively: a double dissociation
    Erin M. Rock
    Cheryl L. Limebeer
    Jordan M. Ward
    Arianne Cohen
    Katherine Grove
    Micah J. Niphakis
    Benjamin F. Cravatt
    Linda A. Parker
    [J]. Psychopharmacology, 2015, 232 : 3841 - 3848
  • [2] Inhibition of Fatty Acid Amide Hydrolase (FAAH) Reduces Contextually Elicited Gaping, a Measure of Anticipatory Nausea in Rats
    Rock, Erin
    Parker, Linda
    Carey, Galen
    Profy, Al
    Currie, Mark
    Segal, Jeffrey
    [J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2014, 109 : S42 - S42
  • [3] Suppression of acute and anticipatory nausea by peripherally restricted fatty acid amide hydrolase inhibitor in animal models: role of PPARα and CB1 receptors
    Rock, Erin M.
    Moreno-Sanz, Guillermo
    Limebeer, Cheryl L.
    Petrie, Gavin N.
    Angelini, Roberto
    Piomelli, Daniele
    Parker, Linda A.
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 2017, 174 (21) : 3837 - 3847
  • [4] Identification of the CB1 cannabinoid receptor and fatty acid amide hydrolase (FAAH) in the human placenta
    Park, B
    Gibbons, HM
    Mitchell, MD
    Glassa, M
    [J]. PLACENTA, 2003, 24 (05) : 473 - 478
  • [5] A comparison of novel, selective fatty acid amide hydrolase (FAAH), monoacyglycerol lipase (MAGL) or dual FAAH/MAGL inhibitors to suppress acute and anticipatory nausea in rat models
    Parker, Linda A.
    Limebeer, Cheryl L.
    Rock, Erin M.
    Sticht, Martin A.
    Ward, Jordan
    Turvey, Greig
    Benchama, Othman
    Rajarshi, Girija
    Wood, JodiAnne T.
    Alapafuja, Shakiru O.
    Makriyannis, Alexandros
    [J]. PSYCHOPHARMACOLOGY, 2016, 233 (12) : 2265 - 2275
  • [6] A comparison of novel, selective fatty acid amide hydrolase (FAAH), monoacyglycerol lipase (MAGL) or dual FAAH/MAGL inhibitors to suppress acute and anticipatory nausea in rat models
    Linda A. Parker
    Cheryl L. Limebeer
    Erin M. Rock
    Martin A. Sticht
    Jordan Ward
    Greig Turvey
    Othman Benchama
    Girija Rajarshi
    JodiAnne T. Wood
    Shakiru O. Alapafuja
    Alexandros Makriyannis
    [J]. Psychopharmacology, 2016, 233 : 2265 - 2275
  • [7] Immunolocalization of cannabinoid receptor 1 (CB1), monoglyceride lipase (MGL) and fatty-acid amide hydrolase 1 (FAAH) in the pig claustrum
    Pirone, Andrea
    Lazzarini, Giulia
    Lenzi, Carla
    Giannessi, Elisabetta
    Miragliotta, Vincenzo
    [J]. JOURNAL OF CHEMICAL NEUROANATOMY, 2020, 109
  • [8] Arachidonylsulfonyl derivatives as cannabinoid CB1 receptor and fatty acid amide hydrolase inhibitors
    Segall, Y
    Quistad, GB
    Nomura, DK
    Casida, JE
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2003, 13 (19) : 3301 - 3303
  • [9] Identification of the CB1 cannabinoid receptor and fatty acid amide hydrolase (FAAH) in the human placenta (vol 24, pg 990, 2003)
    Park, B
    Gibbons, HM
    Mitchell, MD
    Glass, M
    [J]. PLACENTA, 2003, 24 (10) : 990 - 995
  • [10] Immunocytochemical localization of cannabinoid CB1 receptor and fatty acid amide hydrolase in rat retina
    Yazulla, S
    Studholme, KM
    McIntosh, HH
    Deutsch, DG
    [J]. JOURNAL OF COMPARATIVE NEUROLOGY, 1999, 415 (01) : 80 - 90