Meta-analysis demonstrates association between TLR polymorphisms and rheumatoid arthritis

被引:17
|
作者
Lee, Y. H. [1 ]
Bae, S. -C. [2 ]
Song, G. G. [1 ]
机构
[1] Korea Univ, Coll Med, Dept Internal Med, Div Rheumatol, Seoul 136705, South Korea
[2] Hanyang Univ, Dept Internal Med, Med Ctr, Div Rheumatol, Seoul 133791, South Korea
关键词
Toll-like receptor; Polymorphism; Rheumatoid arthritis; TOLL-LIKE RECEPTOR-3; GENE POLYMORPHISMS; SUSCEPTIBILITY; TOLL-LIKE-RECEPTOR-4; THR399ILE; SEVERITY;
D O I
10.4238/2013.February.7.2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We investigated whether Toll-like receptor (TLR) polymorphisms confer susceptibility to rheumatoid arthritis and whether they influence clinical characteristics of rheumatoid arthritis. Studies were considered relevant for our meta-analysis if at least two comparisons of an issue were available. Eleven studies with 2078 patients with rheumatoid arthritis and 2581 controls were included, encompassing European and Asian studies. Meta-analysis of three European studies showed no significant association between the TLR4 Asp299Gly (rs4986790) polymorphism and rheumatoid arthritis (odds ratio = 0.897, 95% confidence interval = 0.734-1.096, P = 0.289). One Turkish study showed a significant difference between TLR9 rs187084 allele frequencies and rheumatoid arthritis patients and controls, while another study revealed a significant association between rheumatoid factor and TLR8 rs5741883. A Korean study on the numbers of guanine-thymine [(GT)(n)] repeats in intron II of the TLR2 gene found a significantly higher S-allele frequency in rheumatoid arthritis patients than in controls (30.3 vs 23.0%). Overall findings for the meta-analysis including all the studies conclude that TLR polymorphism is associated with development and clinical characteristics of rheumatoid arthritis in Asian and Middle East populations.
引用
收藏
页码:328 / 334
页数:7
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