Propanil-induced Histopathological Changes in the Liver and Kidney of Mice

OBJECTIVE: To examine sublethal toxic effects of propanil on liver and kidney of albino Swiss mice, Mus musculus. STUDY DESIGN: Different doses of propanil (75, 150, and 300 mg/kg) were administered to determine histologic defects on liver and kidney tissues of mice for 30 consecutive days. Biometric analyses (area measurements of hepatocyte/nucleus and glomerulus/renal corpuscle) were also conducted to determine whether there were statistical differences in these end points. RESULTS: Cloudy swelling, cytoplasmic vacuolization, nuclear degeneration, nucleus loss, mononuclear cell infiltration, congestion, enlargement of the sinusoids, and increases in the number of Kupffer cells were prominent in the liver of exposed mice. In kidney tissue mononuclear cell infiltration, glomerular degeneration, glomerular loss, and congestion were determined in propanil-treated groups. CONCLUSION: Propanil induced dose-dependent histopathological changes in the liver and kidney tissues of exposed mice. This study showed that propanil exposure might cause harmful effects to nontarget organisms, including humans.