Carboxymethyl cellulose-g-poly (acrylic acid)/calcium phosphate composite as a multifunctional hydrogel material

Multifunctional materials containing calcium phosphate to promote osteogenesis and capable to deliver drugs have gained increasing interest in the field of biomaterials. CMC-g-PAA hydrogel was evaluated to mineralize calcium phosphate during exposure to a solution of simulated body fluid. The formed composite was examined by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), infrared spectroscopy (FT-IR), and thermogravimetric analysis (TGA). The effect of mineralization process onto swelling behavior and drug release capability was evaluated at pH 2.1 and 7.4, similar to that of gastric and intestinal fluids respectively. (C) 2015 Elsevier B.V. All rights reserved.