New Answers to Old Conundrums: What Antibodies, Exosomes and Inflammasomes Bring to the Conversation. Canadian National Transplant Research Program International Summit Report

被引：14

作者：

Dieude, Melanie ^{[1
,2
]}

West, Lori J. ^{[2
,3
,4
,5
,6
]}

Muruve, Daniel A. ^{[2
,7
]}

Gunaratman, Lakshman ^{[2
,8
,9
]}

Mohanakumar, Thalachallour ^{[10
]}

Zorn, Emmanuel ^{[11
]}

Cairo, Christopher W. ^{[12
]}

Freed, Darren H. ^{[2
,13
]}

Schultz, Kirk R. ^{[2
,14
]}

Fairchild, Robert L. ^{[15
]}

Hebert, Marie-Josee ^{[1
,2
]}

机构：

[1] Univ Montreal, CHUM, Ctr Rech, Montreal, PQ, Canada

[2] CNTRP, Edmonton, AB, Canada

[3] Univ Alberta, Dept Pediat, Edmonton, AB, Canada

[4] Univ Alberta, Dept Surg, Edmonton, AB, Canada

[5] Univ Alberta, Dept Immunol, Edmonton, AB, Canada

[6] Alberta Transplant Inst, Edmonton, AB, Canada

[7] Univ Calgary, Snyder Inst Chron Dis, Dept Med, Calgary, AB, Canada

[8] Western Univ, Schulich Sch Med & Dent, London, ON, Canada

[9] Western Univ, Matthew Mailing Ctr Translat Transplant Studies, London, ON, Canada

[10] St Josephs Hosp, Norton Thorac Inst, Phoenix, AZ USA

[11] Columbia Univ, Med Ctr, New York, NY USA

[12] Univ Alberta, Alberta Glyc Ctr, Dept Chem, Edmonton, AB, Canada

[13] Univ Alberta, Fac Med & Dent, Edmonton, AB, Canada

[14] Univ British Columbia, British Columbia Childrens Hospital, Vancouver, BC, Canada

[15] Cleveland Clin, Cleveland, OH 44106 USA

来源：

TRANSPLANTATION | 2018年 / 102卷 / 02期

关键词：

INCOMPATIBLE HEART-TRANSPLANTATION; VERSUS-HOST-DISEASE; KIDNEY INJURY; NLRP3; BLOOD; HLA; TOLERANCE; REJECTION; CELLS; CONTRIBUTES;

D O I：

10.1097/TP.0000000000001872

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antibody-mediated injury is a major cause of allograft dysfunction and loss. Antibodies to ABH(O) blood group antigens are classic mediators of ABO-incompatible graft rejection, whereas donor-specific anti-HLA antibodies and, more recently, autoantibodies are appreciated as important contributors to allograft inflammation and dysfunction. In August 2016, the International Summit of the Canadian National Transplant Research Program focused on recent advances in the field of antibody-mediated rejection. Here, we describe work presented and discussed at the meeting, with a focus on 3 major themes: the importance of (1) natural antibodies and autoantibodies, (2) tissue injury-derived exosomes and autoimmunity, (3) inflammasome activation and innate immune responses in regulating allograft inflammation and dysfunction. Finally, we explore novel areas of therapeutic intervention that have recently emerged from these 3 major and overlapping fields of transplantation research.

引用

页码：209 / 214

页数：6