Enabling Technologies to Advance Microbial Isoprenoid Production

被引：15

作者：

Chen, Yun ^{[1
]}

Zhou, Yongjin J. ^{[1
]}

Siewers, Verena ^{[1
]}

Nielsen, Jens ^{[1
]}

机构：

[1] Chalmers Univ Technol, Syst & Synthet Biol, Dept Chem & Biol Engn, SE-41296 Gothenburg, Sweden

来源：

BIOTECHNOLOGY OF ISOPRENOIDS | 2015年 / 148卷

关键词：

Terpenoids; Sesquiterpenes; Metabolic engineering; Enabling technologies; E; coli; S; cerevisiae; HIGH-LEVEL PRODUCTION; HETEROLOGOUS MEVALONATE PATHWAY; SACCHAROMYCES-CEREVISIAE; ESCHERICHIA-COLI; TAXOL BIOSYNTHESIS; METABOLIC PATHWAYS; CARBENE TRANSFER; SYSTEMS BIOLOGY; HIGH-THROUGHPUT; YEAST;

D O I：

10.1007/10_2014_284

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Microbial production of isoprenoids provides an attractive alternative to biomass extraction and chemical synthesis. Although widespread research aims for isoprenoid biosynthesis, it is still in its infancy in terms of delivering commercial products. Large barriers remain in realizing a cost-competitive process, for example, developing an optimal microbial cell factory. Here, we summarize the many tools and methods that have been developed in the metabolic engineering of isoprenoid production, with the advent of systems biology and synthetic biology, and discuss how these technologies advance to accelerate the design-build-test engineering cycle to obtain optimum microbial systems. It is anticipated that innovative combinations of new and existing technologies will continue to emerge, which will enable further development of microbial cell factories for commercial isoprenoid production.

引用

页码：143 / 160

页数：18

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