Preparation of silk fibroin/collagen/hydroxyapatite composite scaffold by particulate leaching method

被引：27

作者：

Mou, Zhao-Li ^{[1
]}

Duan, Li-Min ^{[1
]}

Qi, Xiao-Ni ^{[2
]}

Zhang, Zhi-Qi ^{[1
,2
]}

机构：

[1] Shaanxi Normal Univ, Key Lab Analyt Chem Life Sci Shaanxi Prov, Sch Chem & Chem Engn, Xian 710062, Peoples R China

[2] Shaanxi Normal Univ, Minist Educ, Key Lab Med Resources & Nat Pharmaceut Chem, Xian 710062, Peoples R China

来源：

MATERIALS LETTERS | 2013年 / 105卷

基金：

中国国家自然科学基金;

关键词：

Preparation; Porous scaffold; Particulate leaching; Microstructure; FIBROIN; HYDROXYAPATITE;

D O I：

10.1016/j.matlet.2013.03.130

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

A novel porous silk fibroin/collagen/hydroxyapatite (SCH) scaffold was one-step fabricated by NaCl particulate leaching method. The interconnected pore network and morphology of SCH scaffolds were determined by environmental scanning electron microscope. The scaffolds exhibited a three-dimensional (3D) porous structure with adjustable macropore size and highly interconnected porosity. The data of EDX, FTIR and XRD spectra confirmed that hydroxyapatite, silk fibroin and collagen had a homogeneous dispersion and a uniform distribution in the scaffolds. The in vitro biocompatibility with osteoblast-like MG-63 cells showed that the scaffolds could significantly promote the proliferation of cells and could be used as a biomedical material. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：189 / 191

页数：3

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