General Anesthetics to Treat Major Depressive Disorder: Clinical Relevance and Underlying Mechanisms

被引:15
|
作者
Vutskits, Laszlo [1 ]
机构
[1] Univ Hosp Geneva, Dept Anesthesiol Pharmacol & Intens Care, 4 Rue Gabrielle Perret Gentil, CH-1211 Geneva 4, Switzerland
来源
ANESTHESIA AND ANALGESIA | 2018年 / 126卷 / 01期
关键词
TREATMENT-RESISTANT DEPRESSION; NMDA RECEPTOR BLOCKADE; OBSESSIVE-COMPULSIVE DISORDER; RAPID ANTIDEPRESSANT RESPONSE; D-ASPARTATE ANTAGONIST; CEREBRAL-BLOOD-FLOW; PROOF-OF-CONCEPT; ELECTROCONVULSIVE-THERAPY; PREFRONTAL CORTEX; SUBANESTHETIC KETAMINE;
D O I
10.1213/ANE.0000000000002594
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Major depressive disorder is a frequent and devastating psychological condition with tremendous public health impact. The underlying pathophysiological mechanisms involve abnormal neurotransmission and a relatedly impaired synaptic plasticity. Since general anesthetics are potent modulators of neuronal activity and, thereby, can exert long-term context-dependent impact on neural networks, an intriguing hypothesis is that these drugs could enhance impaired neural plasticity associated with certain psychiatric diseases. Clinical observations over the past few decades appear to confirm this possibility. Indeed, equipotency of general anesthesia alone in comparison with electroconvulsive therapy under general anesthesia has been demonstrated in several clinical trials. Importantly, in the past 15 years, intravenous administration of subanesthetic doses of ketamine have also been demonstrated to have rapid antidepressant effects. The molecular, cellular, and network mechanisms underlying these therapeutic effects have been partially identified. Although several important questions remain to be addressed, the ensemble of these experimental and clinical observations opens new therapeutic possibilities in the treatment of depressive disorders. Importantly, they also suggest a new therapeutic role for anesthetics that goes beyond their principal use in the perioperative period to facilitate surgery.
引用
收藏
页码:208 / 216
页数:9
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