Cognitive Training Changes Hippocampal Function in Mild Cognitive Impairment: A Pilot Study

被引：112
|
作者：
Rosen, Allyson C. [1 ,2 ,3 ]
Sugiura, Lisa [1 ,3 ]
Kramer, Joel H. [4 ]
Whitfield-Gabrieli, Susan [3 ,5 ]
Gabrieli, John D. [3 ,5 ]
机构：
[1] Stanford Univ, Dept Psychiat, Stanford, CA 94305 USA
[2] Palo Alto Vet Affairs Hlth Care Syst, Palo Alto, CA USA
[3] Stanford Univ, Dept Psychol, Stanford, CA 94305 USA
[4] UCSF Med Ctr, Memory & Aging Ctr, San Francisco, CA USA
[5] MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA
来源：
JOURNAL OF ALZHEIMERS DISEASE | 2011年 / 26卷
关键词：
MRI; dementia; cognition; MCI; mild cognitive impairment; fMRI; functional MRI; cognitive training; hippocampus; medial temporal lobe; MEDIAL TEMPORAL-LOBE; ALZHEIMERS-DISEASE; MEMORY PERFORMANCE; BRAIN PLASTICITY; LEISURE ACTIVITIES; ELDERLY SUBJECTS; FRONTAL-CORTEX; OLDER-ADULTS; LIFE-STYLE; FMRI;
D O I：
10.3233/JAD-2011-0009
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
A randomized pilot experiment examined the neural substrates of response to cognitive training in participants with mild cognitive impairment (MCI). Participants performed exercises previously demonstrated to improve verbal memory and an active control group performed other computer activities. An auditory-verbal fMRI task was conducted before and after the two-month training program. Verbal memory scores improved significantly and left hippocampal activation increased significantly in the experimental group (gains in 5 of 6 participants) relative to the control group (reductions in all 6 participants). Results suggest that the hippocampus in MCI may retain sufficient neuroplasticity to benefit from cognitive training.
引用
收藏
页码：349 / 357
页数：9
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