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Zhejiang Univ, Sch Med, Sch Stomatol,Canc Ctr,Key Lab Oral Biomed Res Zhe, Stomatol Hosp,Zhejiang Prov Clin Res Ctr Oral Dis, Hangzhou 310006, Peoples R China Zhejiang Univ, Sch Med, Sch Stomatol,Canc Ctr,Key Lab Oral Biomed Res Zhe, Stomatol Hosp,Zhejiang Prov Clin Res Ctr Oral Dis, Hangzhou 310006, Peoples R China