A squaraine-based red emission off-on chemosensor for biothiols and its application in living cells imaging

被引：33
|
作者：
Liu, Xiao-Dong [1 ]
Sun, Ru [1 ]
Ge, Jian-Feng [1 ]
Xu, Yu-Jie [2 ]
Xu, Ying [2 ]
Lu, Jian-Mei [1 ]
机构：
[1] Soochow Univ, Key Lab Organ Synth Jiangsu Prov, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Peoples R China
[2] Soochow Univ, Coll Med, Sch Radiat Med & Protect, Suzhou 215123, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2013年 / 11卷 / 25期
基金：
中国国家自然科学基金;
关键词：
FAR-RED; FLUORESCENT; THIOLS; PROBE; CYSTEINE; HOMOCYSTEINE;
D O I：
10.1039/c3ob40502h
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new probe based on the squaraine skeleton with a 2,4-dinitrobenzenesulfonyl unit is reported as a fluorescent probe for biothiol. It shows turn-on properties with red emission towards biothiols in acetonitrile-PBS buffer (1 : 9, v/v) solution, and its properties of rapid response, high selectivity and high sensitivity make it a potential probe with real applications. Moreover, the in vitro assays show that the probe can be used in fluorescence imaging for the detection of intracellular biothiol levels.
引用
收藏
页码：4258 / 4264
页数：7
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