Leukemic Stem Cells: A Review

被引：7
|
作者：
O'Brien, J. A. [1 ]
Rizzieri, D. A. [2 ]
机构：
[1] Duke Univ, Med Ctr, Dept Med Oncol, Durham, NC USA
[2] Duke Univ, Med Ctr, Div Cellular Therapy, Durham, NC USA
来源：
CANCER INVESTIGATION | 2013年 / 31卷 / 04期
关键词：
Leukemia; Leukemic stem cells; Stem cell therapy; ACUTE MYELOID-LEUKEMIA; RECEPTOR-ALPHA CHAIN; CONNECTIVITY MAP; CANCER; PROGENITORS; APOPTOSIS; CD44; EXPRESSION; EFFICACY; COMMON;
D O I：
10.3109/07357907.2012.700986
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A small subset of cells in a patient with leukemia, termed leukemic stem cells (LSCs) have been shown to be responsible for the proliferation of disease. LSCs are thought to derive from normal hematopoietic stem cells, but are phenotypically distinguishable in that they are CD90(-), CD117(-), and CD123(+). Research in mouse models provides several potential therapeutics to target these cells in human patients. Eliminating LSCs should provide an efficient, potentially curative treatment option for leukemia patients.
引用
收藏
页码：215 / 220
页数：6
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