Hematopoietic stem cells and the aging hematopoietic system

被引：67
|
作者：
Gazit, Roi [1 ,2 ]
Weissman, Irving L. [3 ,4 ]
Rossi, Derrick J. [1 ,2 ]
机构：
[1] Harvard Univ, Sch Med, Harvard Stem Cell Inst, Immune Dis Inst, Boston, MA USA
[2] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA
[3] Stanford Univ, Ctr Canc, Stanford Inst Stem Cell Biol & Regenerat Med, Stanford, CA 94305 USA
[4] Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA
来源：
SEMINARS IN HEMATOLOGY | 2008年 / 45卷 / 04期
关键词：
D O I：
10.1053/j.seminhematol.2008.07.010
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The etiology of the age-associated pathophysiological changes of the hematopoietic system including the onset of anemia, diminished adaptive immune competence, and myelogenous disease development are underwritten by the loss of normal homeostatic control. As tissue and organ homeostasis in adults is primarily mediated by the activity of stem and progenitor cells, it has been suggested that the imbalances accompanying aging of the hematopoietic system may stem from alterations in the prevalence and/or functional capacity of hematopoietic stem cells (HSCs) and progenitors. In this review, we examine evidence implicating a role for stem cells in the aging of the hematopoietic system, and focus on the mechanisms suggested to contribute to stem cell aging.
引用
收藏
页码：218 / 224
页数：7
相关论文
共 50 条
  • [1] Stem cells and aging in the hematopoietic system
    Warren, Luigi A.
    Rossi, Derrick J.
    [J]. MECHANISMS OF AGEING AND DEVELOPMENT, 2009, 130 (1-2) : 46 - 53
  • [2] Stem cells and the aging hematopoietic system
    Beerman, Isabel
    Maloney, William J.
    Weissmann, Irving L.
    Rossi, Derrick J.
    [J]. CURRENT OPINION IN IMMUNOLOGY, 2010, 22 (04) : 500 - 506
  • [3] The aging of hematopoietic stem cells
    Morrison, SJ
    Wandycz, AM
    Akashi, K
    Globerson, A
    Weissman, IL
    [J]. NATURE MEDICINE, 1996, 2 (09) : 1011 - 1016
  • [4] Hematopoietic stem cells and aging
    Globerson, A
    [J]. EXPERIMENTAL GERONTOLOGY, 1999, 34 (02) : 137 - 146
  • [5] Aging of hematopoietic stem cells
    de Haan, Gerald
    Lazare, Seka Simone
    [J]. BLOOD, 2018, 131 (05) : 479 - 487
  • [6] Hematopoietic Stem Cells and the Immune System in Development and Aging
    Shevyrev, Daniil
    Tereshchenko, Valeriy
    Berezina, Tatiana N.
    Rybtsov, Stanislav
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (06)
  • [7] Inflammation and hematopoietic stem cells aging
    He, Hanqing
    Wang, Jianwei
    [J]. BLOOD SCIENCE, 2021, 3 (01): : 1 - 5
  • [8] MECHANISMS OF AGING OF HEMATOPOIETIC STEM CELLS
    Geiger, Hartmut
    Florian, Maria Carolina
    [J]. EXPERIMENTAL HEMATOLOGY, 2018, 64 : S29 - S29
  • [9] Aging of the hematopoietic stem cells niche
    Ayako Nakamura-Ishizu
    Toshio Suda
    [J]. International Journal of Hematology, 2014, 100 : 317 - 325
  • [10] Aging of the hematopoietic stem cells niche
    Nakamura-Ishizu, Ayako
    Suda, Toshio
    [J]. INTERNATIONAL JOURNAL OF HEMATOLOGY, 2014, 100 (04) : 317 - 325
12345