Nine Cases of Omeprazole Allergy: Cross-Reactivity Between Proton Pump Inhibitors

被引：1

作者：

Lobera, T. ^{[1
]}

Navarro, B. ^{[1
]}

Del Pozo, M. D. ^{[1
]}

Gonzalez, I. ^{[1
]}

Blasco, A. ^{[1
]}

Escudero, R. ^{[1
]}

Venturini, M. ^{[1
]}

Alarcon, E. ^{[1
]}

机构：

[1] Hosp San Pedro San Millan, Dept Allergy, Logrono, Spain

来源：

JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY | 2009年 / 19卷 / 01期

关键词：

Proton pump inhibitors; Omeprazole; Lansoprazole; Drug allergy; Cross-reactivity; ANAPHYLAXIS; PANTOPRAZOLE; DIAGNOSIS; LANSOPRAZOLE; ANGIOEDEMA; SHOCK;

D O I：

暂无

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Although rare, anaphylactic reactions induced by proton pump inhibitors have been reported. The presence of cross-reactivity between different members of the group is not clear. We studied 9 patients with adverse reactions to omeprazole, Clinical symptoms appeared immediately in 8 patients and after 4 hours in 1. Symptoms ranged from urticaria/angioedema in 7 cases to anaphylaxis in 2 cases. Skin prick tests and oral controlled challenge tests with omeprazole, lansoprazole, and pantoprazole were performed. Skin prick or intradermal tests with omeprazole were positive in 8 patients. Four were also positive to pantoprazole. Prick tests with lansoprazole were always negative. Lansoprazole was administered to all 9 patients, with good tolerance in 8. Only 3 patients were challenged with pantoprazole and developed widespread urticaria. We present 9 patients with immunoglobulin E-mediated allergy to omeprazole. In most of our cases, lansoprazole proved to be a good alternative treatment.

引用

页码：57 / 60

页数：4

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