Oxidative Cleavage Products of Lycopene: Production and Reactivity in a Biomimetic Experimental Model of Oxidative Stress

被引：0
|
作者：
Carail, Michel [1 ]
Goupy, Pascale [1 ]
Reynaud, Eric [1 ]
Dangles, Olivier [1 ]
Caris-Veyrat, Catherine [1 ]
机构：
[1] INRA, Secur & Qual Prod Origine Vegetale UMR408, F-84000 Avignon, France
来源：
CAROTENOID CLEAVAGE PRODUCTS | 2013年 / 1134卷
关键词：
HEME-INDUCED PEROXIDATION; CAROTENOIDS IN-VITRO; DIETARY ANTIOXIDANTS; RETINOIC ACID; LINOLEIC-ACID; BETA-CAROTENE; LUNG-CANCER; METABOLITES; INHIBITION; STOMACH;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Carotenoids oxidation products are of interest for their possible biological activity. We produced and characterized a series of lycopene oxidative cleavage products by oxidizing lycopene. We synthesized apo-lycopenoids of various polyene chain lengths and terminal functions. Antioxidant activity of apo-lycopenoids was determined using a lipid peroxidation test mimicking oxidative stress in the gastro-intestinal tract. Results allowed us to establish structure-activity relationships of antioxidant protection of apo-lycopenoids in the gastro-intestinal tract. A long carbon chain and a carboxylic acid endgroup conferring an amphiphilic character to the molecule are favorable to the antioxidant activity of apo-lycopenoids.
引用
收藏
页码：191 / 205
页数：15
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