The Emerging Role of Circular RNAs in Hepatocellular Carcinoma
被引:67
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作者:
Qiu, Li-Peng
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Jiangsu Univ, Inst Life Sci, Zhenjiang 212013, Jiangsu, Peoples R ChinaJiangsu Univ, Inst Life Sci, Zhenjiang 212013, Jiangsu, Peoples R China
Qiu, Li-Peng
[1
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Wu, Yi-Hang
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机构:
China Jiliang Univ, Coll Life Sci, Dept Pharm, Hangzhou 310018, Zhejiang, Peoples R ChinaJiangsu Univ, Inst Life Sci, Zhenjiang 212013, Jiangsu, Peoples R China
Wu, Yi-Hang
[2
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Yu, Xiao-Feng
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机构:
Jiangsu Univ, Sch Pharm, Zhenjiang 212013, Jiangsu, Peoples R ChinaJiangsu Univ, Inst Life Sci, Zhenjiang 212013, Jiangsu, Peoples R China
Yu, Xiao-Feng
[3
]
Tang, Qi
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Jiangsu Univ, Inst Life Sci, Zhenjiang 212013, Jiangsu, Peoples R ChinaJiangsu Univ, Inst Life Sci, Zhenjiang 212013, Jiangsu, Peoples R China
Tang, Qi
[1
]
Chen, Liang
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Jiangsu Univ, Inst Life Sci, Zhenjiang 212013, Jiangsu, Peoples R ChinaJiangsu Univ, Inst Life Sci, Zhenjiang 212013, Jiangsu, Peoples R China
Chen, Liang
[1
]
Chen, Ke-Ping
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Jiangsu Univ, Inst Life Sci, Zhenjiang 212013, Jiangsu, Peoples R ChinaJiangsu Univ, Inst Life Sci, Zhenjiang 212013, Jiangsu, Peoples R China
Chen, Ke-Ping
[1
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机构:
[1] Jiangsu Univ, Inst Life Sci, Zhenjiang 212013, Jiangsu, Peoples R China
[2] China Jiliang Univ, Coll Life Sci, Dept Pharm, Hangzhou 310018, Zhejiang, Peoples R China
[3] Jiangsu Univ, Sch Pharm, Zhenjiang 212013, Jiangsu, Peoples R China
Hepatocellular carcinoma (HCC) ranks the third leading cause of cancer death in the world and has a notably low survival rate. Circular RNAs (circRNAs) are newly classed non-coding RNA (ncRNA) members that are capable of regulating gene expression at transcription or post-transcription levels. Recent studies demonstrate that some circRNAs are differentially expressed in HCC, and the deregulation of these circRNAs is associated with the clinical pathological and prognostic significance. They also play essential roles in HCC progression, and contribute to cell proliferation, migration, invasion and metastasis by targeting different microRNAs (miRNAs) and protein-coding genes. In this review, we concentrate on recent progress of some important circRNAs in HCC, with an emphasis on their deregulation, functions and regulatory mechanisms, and discuss their potential utility as diagnostic and/or prognostic biomarkers or therapeutic targets for HCC.
机构:
German Int Univ GIU, Fac Biotechnol, Biol & Biochem Dept, Mol Genet Res Team MGRT, Cairo 11835, Egypt
Cairo Univ, Fac Sci, Biotechnol Biomol Chem Program, Giza 12613, EgyptGerman Int Univ GIU, Fac Biotechnol, Biol & Biochem Dept, Mol Genet Res Team MGRT, Cairo 11835, Egypt
Abaza, Tasneem
Abd El-Aziz, Mostafa K.
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German Int Univ GIU, Fac Biotechnol, Biol & Biochem Dept, Mol Genet Res Team MGRT, Cairo 11835, Egypt
Al Azhar Univ, Fac Pharm, Biochem Dept, Assiut Branch, Assiut 71631, EgyptGerman Int Univ GIU, Fac Biotechnol, Biol & Biochem Dept, Mol Genet Res Team MGRT, Cairo 11835, Egypt
Abd El-Aziz, Mostafa K.
Daniel, Kerolos Ashraf
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机构:
German Int Univ GIU, Fac Biotechnol, Biol & Biochem Dept, Mol Genet Res Team MGRT, Cairo 11835, Egypt
Univ Hertfordshire, Sch Life & Med Sci, Biol & Biochem Dept, Mol Genet Res Team MGRT,Global Acad Fdn, Cairo 11835, EgyptGerman Int Univ GIU, Fac Biotechnol, Biol & Biochem Dept, Mol Genet Res Team MGRT, Cairo 11835, Egypt
Daniel, Kerolos Ashraf
Karousi, Paraskevi
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机构:
Natl & Kapodistrian Univ Athens, Dept Biochem & Mol Biol, Fac Biol, Athens 15701, GreeceGerman Int Univ GIU, Fac Biotechnol, Biol & Biochem Dept, Mol Genet Res Team MGRT, Cairo 11835, Egypt
Karousi, Paraskevi
Papatsirou, Maria
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Natl & Kapodistrian Univ Athens, Dept Biochem & Mol Biol, Fac Biol, Athens 15701, GreeceGerman Int Univ GIU, Fac Biotechnol, Biol & Biochem Dept, Mol Genet Res Team MGRT, Cairo 11835, Egypt
Papatsirou, Maria
Fahmy, Sherif Ashraf
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机构:
Univ Hertfordshire, Sch Life & Med Sci, Dept Chem, Global Acad Fdn, R5 New Garden City, Cairo 11835, EgyptGerman Int Univ GIU, Fac Biotechnol, Biol & Biochem Dept, Mol Genet Res Team MGRT, Cairo 11835, Egypt
Fahmy, Sherif Ashraf
Hamdy, Nadia M.
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机构:
Ain Shams Univ, Fac Pharm, Biochem Dept, Cairo 11566, EgyptGerman Int Univ GIU, Fac Biotechnol, Biol & Biochem Dept, Mol Genet Res Team MGRT, Cairo 11835, Egypt
Hamdy, Nadia M.
Kontos, Christos K.
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机构:
Natl & Kapodistrian Univ Athens, Dept Biochem & Mol Biol, Fac Biol, Athens 15701, GreeceGerman Int Univ GIU, Fac Biotechnol, Biol & Biochem Dept, Mol Genet Res Team MGRT, Cairo 11835, Egypt
Kontos, Christos K.
Youness, Rana A.
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German Int Univ GIU, Fac Biotechnol, Biol & Biochem Dept, Mol Genet Res Team MGRT, Cairo 11835, EgyptGerman Int Univ GIU, Fac Biotechnol, Biol & Biochem Dept, Mol Genet Res Team MGRT, Cairo 11835, Egypt
机构:
Jilin Univ, Sci Res Ctr, China Japan Union Hosp, Changchun, Peoples R ChinaJilin Univ, Sci Res Ctr, China Japan Union Hosp, Changchun, Peoples R China
Zhang, Yucheng
Wang, Yali
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机构:
Jilin Univ, Dept Blood Transfus, China Japan Union Hosp, Changchun, Peoples R ChinaJilin Univ, Sci Res Ctr, China Japan Union Hosp, Changchun, Peoples R China
机构:
Univ Witwatersrand, Fac Hlth Sci, Sch Pathol, Wits SAMRC Antiviral Gene Therapy Res Unit, Johannesburg, South AfricaUniv Witwatersrand, Fac Hlth Sci, Sch Pathol, Wits SAMRC Antiviral Gene Therapy Res Unit, Johannesburg, South Africa
Ely, Abdullah
Bloom, Kristie
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机构:
Univ Witwatersrand, Fac Hlth Sci, Sch Pathol, Wits SAMRC Antiviral Gene Therapy Res Unit, Johannesburg, South AfricaUniv Witwatersrand, Fac Hlth Sci, Sch Pathol, Wits SAMRC Antiviral Gene Therapy Res Unit, Johannesburg, South Africa
Bloom, Kristie
Maepa, Mohube Betty
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机构:
Univ Witwatersrand, Fac Hlth Sci, Sch Pathol, Wits SAMRC Antiviral Gene Therapy Res Unit, Johannesburg, South AfricaUniv Witwatersrand, Fac Hlth Sci, Sch Pathol, Wits SAMRC Antiviral Gene Therapy Res Unit, Johannesburg, South Africa
Maepa, Mohube Betty
Arbuthnot, Patrick
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机构:
Univ Witwatersrand, Fac Hlth Sci, Sch Pathol, Wits SAMRC Antiviral Gene Therapy Res Unit, Johannesburg, South AfricaUniv Witwatersrand, Fac Hlth Sci, Sch Pathol, Wits SAMRC Antiviral Gene Therapy Res Unit, Johannesburg, South Africa
机构:
Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical UniversityOrgan Transplantation Center, The First Affiliated Hospital of Kunming Medical University
Yuan Fang
Yang Yang
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机构:
Department of Otorhinolaryngology, The First Affiliated Hospital of Kunming Medical UniversityOrgan Transplantation Center, The First Affiliated Hospital of Kunming Medical University
Yang Yang
Na Li
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机构:
Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical UniversityOrgan Transplantation Center, The First Affiliated Hospital of Kunming Medical University
Na Li
Xiao-Li Zhang
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机构:
Department of Gastrointestinal and Hernia Surgery, The First Affiliated Hospital of Kunming Medical UniversityOrgan Transplantation Center, The First Affiliated Hospital of Kunming Medical University
Xiao-Li Zhang
Han-Fei Huang
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机构:
Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical UniversityOrgan Transplantation Center, The First Affiliated Hospital of Kunming Medical University
机构:
Tianjin Med Univ Canc Inst & Hosp, Dept Gastrointestinal Canc Biol, Tianjin, Peoples R China
Key Lab Canc Immunol & Biotherapy, Tianjin, Peoples R China
Natl Clin Res Ctr Canc, Tianjin, Peoples R ChinaTianjin Med Univ Canc Inst & Hosp, Dept Gastrointestinal Canc Biol, Tianjin, Peoples R China
Liu, Jing
Zhang, Xin
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机构:
Tianjin Med Univ Canc Inst & Hosp, Dept Gastrointestinal Canc Biol, Tianjin, Peoples R China
Key Lab Canc Immunol & Biotherapy, Tianjin, Peoples R China
Natl Clin Res Ctr Canc, Tianjin, Peoples R ChinaTianjin Med Univ Canc Inst & Hosp, Dept Gastrointestinal Canc Biol, Tianjin, Peoples R China
Zhang, Xin
Yan, Meinan
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机构:
Tianjin Med Univ Canc Inst & Hosp, Dept Gastrointestinal Canc Biol, Tianjin, Peoples R China
Key Lab Canc Immunol & Biotherapy, Tianjin, Peoples R China
Natl Clin Res Ctr Canc, Tianjin, Peoples R ChinaTianjin Med Univ Canc Inst & Hosp, Dept Gastrointestinal Canc Biol, Tianjin, Peoples R China
Yan, Meinan
Li, Hui
论文数: 0引用数: 0
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机构:
Tianjin Med Univ Canc Inst & Hosp, Dept Gastrointestinal Canc Biol, Tianjin, Peoples R China
Key Lab Canc Immunol & Biotherapy, Tianjin, Peoples R China
Natl Clin Res Ctr Canc, Tianjin, Peoples R ChinaTianjin Med Univ Canc Inst & Hosp, Dept Gastrointestinal Canc Biol, Tianjin, Peoples R China
机构:
Laboratory of Micromorphology, School of Basic Medicine, Qingdao UniversityLaboratory of Micromorphology, School of Basic Medicine, Qingdao University