The Emerging Role of Circular RNAs in Hepatocellular Carcinoma

被引:67
|
作者
Qiu, Li-Peng [1 ]
Wu, Yi-Hang [2 ]
Yu, Xiao-Feng [3 ]
Tang, Qi [1 ]
Chen, Liang [1 ]
Chen, Ke-Ping [1 ]
机构
[1] Jiangsu Univ, Inst Life Sci, Zhenjiang 212013, Jiangsu, Peoples R China
[2] China Jiliang Univ, Coll Life Sci, Dept Pharm, Hangzhou 310018, Zhejiang, Peoples R China
[3] Jiangsu Univ, Sch Pharm, Zhenjiang 212013, Jiangsu, Peoples R China
来源
JOURNAL OF CANCER | 2018年 / 9卷 / 09期
基金
中国国家自然科学基金;
关键词
circRNA; HCC; liver cancer; miRNA sponge; biomarker; proliferation; LONG NONCODING RNAS; CELL-PROLIFERATION; TUMOR-SUPPRESSOR; PROFILING REVEALS; SIGNALING PATHWAY; UBIQUITIN LIGASE; GASTRIC-CANCER; EXPRESSION; INVASION; MIGRATION;
D O I
10.7150/jca.24566
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Hepatocellular carcinoma (HCC) ranks the third leading cause of cancer death in the world and has a notably low survival rate. Circular RNAs (circRNAs) are newly classed non-coding RNA (ncRNA) members that are capable of regulating gene expression at transcription or post-transcription levels. Recent studies demonstrate that some circRNAs are differentially expressed in HCC, and the deregulation of these circRNAs is associated with the clinical pathological and prognostic significance. They also play essential roles in HCC progression, and contribute to cell proliferation, migration, invasion and metastasis by targeting different microRNAs (miRNAs) and protein-coding genes. In this review, we concentrate on recent progress of some important circRNAs in HCC, with an emphasis on their deregulation, functions and regulatory mechanisms, and discuss their potential utility as diagnostic and/or prognostic biomarkers or therapeutic targets for HCC.
引用
收藏
页码:1548 / 1559
页数:12
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