Low expression of CD80 predicts for poor prognosis in patients with gastric adenocarcinoma

被引：20

作者：

Feng, Xing-yu ^{[1
,2
,3
]}

Lu, Lin ^{[4
,5
]}

Wang, Ke-feng ^{[1
,3
]}

Zhu, Bao-yan ^{[1
,3
]}

Wen, Xi-zhi ^{[1
,3
]}

Peng, Rui-qing ^{[1
,3
]}

Ding, Ya ^{[1
,3
]}

Li, Dan-dan ^{[1
,3
]}

Li, Jing-jing ^{[1
,3
]}

Li, Yong ^{[2
]}

Zhang, Xiao-shi ^{[1
,3
]}

机构：

[1] Sun Yat Sen Univ, Ctr Canc, Biotherapy Ctr, 651 Dongfeng Rd East, Guangzhou 510060, Guangdong, Peoples R China

[2] South China Univ Technol, Sch Med, Guangdong Acad Med Sci, Dept Gen Surg,Guangdong Gen Hosp, 106 Zhongshan Rd 2, Guangzhou 510080, Guangdong, Peoples R China

[3] State Key Lab Oncol South China, 651 Dongfeng Rd East, Guangzhou 510060, Guangdong, Peoples R China

[4] South China Univ Technol, Sch Med, Guangzhou Peoples Hosp 1, Dept Med Oncol, Guangzhou 510180, Guangdong, Peoples R China

[5] Guangzhou Med Univ, Guangzhou Peoples Hosp 1, Dept Med Oncol, 602 Renminbei Rd, Guangzhou 510180, Guangdong, Peoples R China

来源：

FUTURE ONCOLOGY | 2019年 / 15卷 / 05期

基金：

中国国家自然科学基金;

关键词：

CD80; cytotoxic T lymphocytes; gastric cancer; prognosis; CD8(+) T-CELLS; COSTIMULATORY MOLECULES; TUMOR-IMMUNITY; B7-1; CD80; CANCER; LYMPHOCYTES; SURVIVAL; LINE; CD28;

D O I：

10.2217/fon-2018-0420

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: To study the expression and prognostic significance of CD80 in patients with gastric adenocarcinoma. Materials& methods: Real-time quantitative PCR, western blot and immunohistochemistry were performed to detect the expression of CD80 in gastric cancer tissues and matched adjacent normal tissues. Double immunohistochemical staining was performed to preliminary examine the relationship between CD80(+) cells and CD8(+) cytotoxic T lymphocytes. Results: The expression of CD80 was downregulated in tumor tissues compared with normal tissues (p =0.002). Immunohistochemistry analysis showed that 49 (39.8%) of 123 patients with gastric cancer demonstrated reduced CD80 expression, which was correlated with the tumor differentiation grade. Conclusion: Our data suggest that reduced CD80 expression independently predicts a poor prognosis in patients with gastric adenocarcinoma.

引用

页码：473 / 483

页数：11

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