4-(Dimethylamino)pyridine as a catalyst for the lactonization of 4-hydroxy-2-methylenebutanoate esters

被引：9
|
作者：
Nicponski, Daniel R. [1 ]
机构：
[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA
来源：
TETRAHEDRON LETTERS | 2014年 / 55卷 / 13期
关键词：
Lactonization; Cyclization; Esterification; Catalysis; Green chemistry; BAYLIS-HILLMAN ADDUCTS; GAMMA-BUTYROLACTONES; KAPPA-B; DMAP; PARTHENOLIDE; ALDEHYDES; CANCER; CYCLOADDITION; ADDITIONS; LACTONE;
D O I：
10.1016/j.tetlet.2014.02.024
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The catalytic action of 4-(dimethylamino)pyridine (DMAP) in lactonizing 4-hydroxy-2-methylenebutanoate esters to 2-methylene-gamma-butyrolactones is described. The use of DMAP, which functions as an excellent complement to the more traditional acid-catalyzed lactonization protocol, allows for the synthesis of 2-methylene-gamma-butyrolactones containing acid-sensitive groups under essentially neutral conditions. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2075 / 2077
页数：3
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