Interleukin-1 beta specifically stimulates nitric oxide production in the hypothalamus

被引：11
|
作者：
Brunetti, L
Volpe, AR
Ragazzoni, E
Preziosi, P
Vacca, M
机构：
[1] UNIV G DANNUNZIO, FAC FARM, INST SCI FARM, I-66100 CHIETI, ITALY
[2] CATHOLIC UNIV, CNR, RECEPTOR CHEM CTR, I-00168 ROME, ITALY
来源：
LIFE SCIENCES | 1996年 / 58卷 / 25期
关键词：
interleukin-1; beta; nitric oxide; CRH;
D O I：
10.1016/0024-3205(96)00238-X
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
In previous experiments we have shown the role of nitric oxide (NO) in basal and interleukin-1 beta (IL-1 beta)-induced CRH and ACTH release in vitro. Now, we have studied the possible production of NO from hypothalamic cell cultures, particularly after IL-1 beta stimulation or L-NOArg inhibition, by high performance liquid chromatographic (HPLC) assay of L-citrulline production, adding further evidence for a role of NO in IL-1 beta activity in the hypothalamus.
引用
收藏
页码：PL373 / PL377
页数：5
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