ApoE genotypes are associated with age at natural menopause in Chinese females

被引:17
|
作者
Meng, Fan-Tao [2 ]
Wang, Yan-Li [3 ]
Liu, Ji [2 ]
Zhao, Jun [2 ]
Liu, Rong-Yu [3 ]
Zhou, Jiang-Ning [1 ,2 ]
机构
[1] USTC, Sch Life Sci, Dept Neurobiol & Biophys, Hefei 230027, Anhui, Peoples R China
[2] Univ Sci & Technol China, Sch Life Sci, CAS Key Lab Brain Funct & Dis, Hefei 230027, Anhui, Peoples R China
[3] Anhui Med Univ, Affiliated Hosp 1, Anhui Geriatr Inst, Dept Endocrinol, Hefei, Peoples R China
基金
中国国家自然科学基金;
关键词
ApoE genotype; Age at menopause; Age at menarche; GENOME-WIDE ASSOCIATION; APOLIPOPROTEIN-E GENOTYPE; BODY-SIZE; EPSILON-4; CARRIERS; GENETIC INFLUENCES; PREDICTIVE FACTORS; CAUCASIAN FEMALES; ALZHEIMER-DISEASE; MENARCHE; WOMEN;
D O I
10.1007/s11357-011-9287-4
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Ages at natural menarche and menopause are influenced by several genetic factors. This study aimed to investigate the possible relationship between the apolipoprotein E (ApoE) genotype and the age at menarche and natural menopause in Chinese females. In the current study, 398 (elderly group, aged 47-80 years) and 825 (young group, aged 15-25 years) Chinese females were enrolled under informed content. Ages at natural menarche and menopause were obtained by questionnaires. ApoE genotypes were identified by restriction fragment length polymorphism analysis. In the elderly group, the number of pregnancies and live births and breastfeeding were associated with the age at menopause (P = 0.008, P = 0.002, and P = 0.023, respectively). One-way ANOVA analysis revealed that the ApoE genotype was significantly associated with age at natural menopause (ANM; P = 0.010). Compared with ApoE epsilon 3/3 carriers, ApoE epsilon 3/4 females showed a 1.8-year delay in ANM (P = 0.002). Single ApoE allele-positive/allele-negative analysis also showed that the age at menopause of ApoE epsilon 4 carriers was delayed compared with those who were not carriers (P = 0.023). In the young group, no statistical difference was found in the age of menarche between the carriers of ApoE epsilon 3/3 and epsilon 3/4. Single ApoE allele-positive/allele-negative analysis showed that the age at menarche in ApoE epsilon 4 carriers was slightly earlier than in those who were not carriers (P = 0.048). Meanwhile, univariate association analysis revealed that the ApoE genotypes were not significantly associated with the age at menarche using age as a covariate in the pooled group (young + elderly) (P = 0.143). We demonstrated that the ApoE genotype is significantly linked to the age at natural menopause.
引用
收藏
页码:1023 / 1032
页数:10
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