The International Mouse Phenotyping Consortium: past and future perspectives on mouse phenotyping

被引：211
|
作者：
Brown, Steve D. M. [1 ]
Moore, Mark W. [2 ]
机构：
[1] MRC Harwell, MRC Mammalian Genet Unit, Didcot OX11 0RD, Oxon, England
[2] NHGRI, Int Mouse Phenotyping Consortium, NIH, Bethesda, MD 20892 USA
来源：
MAMMALIAN GENOME | 2012年 / 23卷 / 9-10期
基金：
英国医学研究理事会;
关键词：
FUNCTIONAL ANNOTATION; RESOURCE; GENOME; EUROPHENOME; MICROSCOPY; MORPHOLOGY; EMPRESS;
D O I：
10.1007/s00335-012-9427-x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Determining the function of all mammalian genes remains a major challenge for the biomedical science community in the 21st century. The goal of the International Mouse Phenotyping Consortium (IMPC) over the next 10 years is to undertake broad-based phenotyping of 20,000 mouse genes, providing an unprecedented insight into mammalian gene function. This short article explores the drivers for large-scale mouse phenotyping and provides an overview of the aims and processes involved in IMPC mouse production and phenotyping.
引用
收藏
页码：632 / 640
页数：9
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