Synthetic approaches and pharmaceutical applications of chloro-containing molecules for drug discovery: A critical review

被引：169

作者：

Fang, Wan-Yin ^{[1
]}

Ravindar, L. ^{[1
]}

Rakesh, K. P. ^{[1
]}

Manukumar, H. M. ^{[2
]}

Shantharam, C. S. ^{[3
]}

Alharbi, Njud S. ^{[4
]}

Qin, Hua-Li ^{[1
]}

机构：

[1] Wuhan Univ Technol, Sch Mat Sci & Engn, Sch Chem Chem Engn & Life Sci, 205 Luoshi Rd, Wuhan 430070, Peoples R China

[2] Sri Jayachamarajendra Coll Engn, Dept Chem, Mysuru 570006, Karnataka, India

[3] Pooja Bhagavath Mem Mahajana Educ Ctr, Dept Chem, Mysuru 570016, Karnataka, India

[4] King Abdulaziz Univ, Fac Sci, Dept Biol Sci, Biotechnol Res Grp, Jeddah, Saudi Arabia

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2019年 / 173卷

基金：

中国国家自然科学基金;

关键词：

Synthesis; Chlorinated compounds; Biological applications; SAR; TARGET-DIRECTED LIGANDS; BIOLOGICAL EVALUATION; SELECTIVE INHIBITORS; ALZHEIMERS-DISEASE; DERIVATIVES SYNTHESIS; RECEPTOR ANTAGONISTS; DESIGN; POTENT; DOCKING; ANTIBACTERIAL;

D O I：

10.1016/j.ejmech.2019.03.063

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

At present more than 250 FDA approved chlorine containing drugs were available in the market and many pharmaceutically important drug candidates in pre-clinical trials. Thus, it is quite obvious to expect that in coming decades there will be an even greater number of new chlorine-containing pharmaceuticals in market. Chlorinated compounds represent the family of compounds promising for use in medicinal chemistry. This review describes the recent advances in the synthesis of chlorine containing heterocyclic compounds as diverse biological agents and drugs in the pharmaceutical industries for the inspiration of the discovery and development of more potent and effective chlorinated drugs against numerous death-causing diseases. (C) 2019 Elsevier Masson SAS. All rights reserved.

引用

页码：117 / 153

页数：37

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