Atypical Hand, Foot, and Mouth Disease Caused by Coxsackievirus A6 in Denmark: A Diagnostic Mimicker

被引:30
|
作者
Horsten, Hans-Henrik [1 ,2 ]
Kemp, Michael [3 ]
Fischer, Thea K. [4 ,5 ,6 ]
Lindahl, Kim H. [7 ]
Bygum, Anette [1 ,2 ]
机构
[1] Odense Univ Hosp, Dept Dermatol, DK-5000 Odense C, Denmark
[2] Odense Univ Hosp, Allergy Ctr, DK-5000 Odense C, Denmark
[3] Univ Southern Denmark, Dept Clin Microbiol, Odense Univ Hosp, Odense, Denmark
[4] Statens Serum Inst, Virol Surveillance & Res Sect, Dept Microbiol Diagnost & Virol, Copenhagen, Denmark
[5] Univ Southern Denmark, Clin Inst, Odense, Denmark
[6] Univ Southern Denmark, Ctr Global Hlth, Odense, Denmark
[7] Odense Univ Hosp, Dept Clin Pathol, Odense, Denmark
关键词
atypical hand; foot; and mouth disease; Coxsackievirus A6; diagnostic mimicker; ECZEMA COXSACKIUM; ENTEROVIRUS; 71; OUTBREAK; A10;
D O I
10.2340/00015555-2853
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Since 2008, outbreaks of atypical hand, foot, and mouth disease (HFMD) in children and adults have been reported worldwide. The majority of these outbreaks are caused by a new lineage of Coxsackie virus A6 (CV-A6) presenting a more severe clinical phenotype than the classical childhood HFMD caused by CV-A16. Between June 2014 and January 2016, 23 cases of atypical HFMD disease presented at a Dermatology Department at a regional University Hospital in Denmark. Patients were referred by general practitioners and dermatologists with a variety of clinical diagnoses, including eczema herpeticum, vasculitis, syphilis, dermatophytid, erythema multiforme and Stevens-Johnson syndrome. Three adults and 3 children required hospitalization due to extensive skin involvement and fever. All reported patients had laboratory-confirmed enterovirus infection. This study demonstrated an up-surge in atypical HFMD caused by CV-A6 in the Region of Southern Denmark and that atypical HFMD can be difficult to diagnose clinically as it may mimic other severe skin diseases.
引用
收藏
页码:350 / 354
页数:5
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