The expressions of TC1 (C8orf4) and β-catenin were correlated with the malignant phenotype of gliomas and meningiomas

TC1 (Thyroid cancer 1, C8orf4) can enhance the transcriptional activity of Wnt/beta-catenin signaling pathway, and plays important role in tumor development. We investigated the correlations of TC1 and beta-catenin in gliomas and meningiomas. The expressions of TC1 and beta-catenin were examined in 86 gliomas and 75 meningiomas using immunohistochemistry method. The expression of TC1 was positive in 81 (81/86, 96.19%) gliomas and 69 (69/75, 92.00%) meningiomas, and correlated with the advanced WHO grade both in gliomas and meningiomas. The expression of beta-catenin was positive in 63 (63/86, 73.26%) gliomas and 67 (67/75, 89.33%) meningiomas, and correlated with the advanced WHO grade of meningiomas. The expression of TC1 was positively correlated with the expression of beta-catenin in gliomas or meningiomas, respectively. Moreover, the nuclear expression of TC1 was observed in 33 gliomas and 11 meningiomas. The nuclear expression rate of TC1 was significantly higher in gliomas than that in meningiomas. In conclusion, the expressions of TC1 and beta-catenin were correlated with the malignant phenotype in both gliomas and meningiomas. TC1 may co-express with beta-catenin, and promote the malignant transformation of gliomas and meningiomas.