Development of a one-pot sequential Sonogashira coupling for the synthesis of benzofurans

被引：59
|
作者：
Csekei, Marton [1 ]
Novak, Zoltan [1 ]
Kotschy, Andras [1 ]
机构：
[1] Eotvos Lorand Univ, Inst Chem, H-1117 Budapest, Hungary
来源：
TETRAHEDRON | 2008年 / 64卷 / 37期
基金：
匈牙利科学研究基金会;
关键词：
D O I：
10.1016/j.tet.2008.05.100
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient one-pot protocol was developed for the construction of the benzofuran system from aryl halides and protected iodophenols using carbinol-based acetylene sources. The sequence includes alternating palladium-catalyzed Sonogashira couplings and deprotection steps concluded by a ring closure. The developed one-pot procedure was compared with the stepwise approach and its efficiency was also demonstrated by the total synthesis of vignafuran a benzofuran natural product. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：8992 / 8996
页数：5
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