Nickel-Catalyzed Intramolecular Direct Arylation of lmines toward Diverse Indoles

被引：17
|
作者：
Long, Han [1 ,2 ,3 ]
Xu, Kunhua [1 ,2 ,3 ]
Chen, Shanshan [1 ,2 ,3 ]
Lin, Jin [1 ,2 ,3 ]
Wu, Dan [1 ,2 ,3 ]
Wu, Bo [1 ,2 ,3 ]
Tian, Xu [1 ,2 ,3 ]
Ackermann, Lutz [4 ]
机构：
[1] Guangzhou Med Univ, Sch Pharmaceut Sci, Key Lab Mol Target & Clin Pharmacol, Guangzhou 511436, Guangdong, Peoples R China
[2] Guangzhou Med Univ, Sch Pharmaceut Sci, State Key Lab Resp Dis, Guangzhou 511436, Guangdong, Peoples R China
[3] Guangzhou Med Univ, Affiliated Hosp 5, Guangzhou 511436, Guangdong, Peoples R China
[4] Georg August Univ, Inst Organ & Biomol Chem, Tammannstr 2, D-37077 Gottingen, Germany
来源：
ORGANIC LETTERS | 2019年 / 21卷 / 09期
基金：
美国国家科学基金会;
关键词：
COUPLING REACTIONS; HECK REACTION; CARBOCYCLIC CARBENE; CASCADE REACTIONS; C-C; COMPLEXES; EFFICIENT; CONSTRUCTION; DERIVATIVES; CHLORIDES;
D O I：
10.1021/acs.orglett.9b00600
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient nickel-catalyzed intramolecular direct arylation of imines with challenging aryl chlorides has been developed. The versatile nickel catalysis made use of easily accessible imines and delivered diversely decorated 2-arylindoles of considerable importance to biological and medicinal chemistry.
引用
收藏
页码：3053 / 3056
页数：4
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