Antithrombotic therapy for stroke prevention in patients with atrial fibrillation in Japan

Introduction Stroke remains one of the major public health problems in Japan. The number of patients with atrial fibrillation (AF) has been steadily increasing with the aging of the Japanese population. Appropriate oral antithrombotic therapy is necessary to prevent AF-related stroke and bleeding complications. Areas covered The authors summarize the Japanese guidelines for antithrombotic therapy, as well as the current status of antithrombotic therapy, and future perspectives for antithrombotic therapy for patients with AF in Japan. Expert opinion Further improvement in adherence to guideline-recommended warfarin therapy may be difficult to achieve. After the introduction of direct oral anticoagulants (DOACs) into clinical practice, the proportion of patients with AF receiving oral anticoagulant therapy has increased in Japan. However, the proportion of patients treated with inappropriately reduced doses of DOACs has also been increasing. Inappropriate dose reduction of DOACs simply because of advanced age should be avoided to reduce stroke events in patients with AF. Among patients with AF receiving anticoagulant therapy who have coronary artery disease, inappropriately prolonged triple therapy or dual therapy should be avoided to reduce major bleeding complications. Shortening the duration of triple therapy or dual therapy may be promoted by simplified recommendations in the 2020-updated guidelines supported by solid evidence.