Management of thrombosis in a pediatric renal transplant patient with factor VII deficiency A dilemma concerning recombinant factor VIIa

被引：0

作者：

Yalcin, M. ^{[1
]}

Simsek, A. ^{[2
]}

Tabel, Y. ^{[3
]}

Dogan, S. M. ^{[2
]}

Piskin, T. ^{[2
]}

机构：

[1] Sanliurfa Mehmet Akif Man Training & Res Hosp, Dept Gen Surg, Sanliurfa, Turkey

[2] Inonu Univ, Sch Med, Turgut Ozal Med Ctr, Dept Gen Surg, Malatya, Turkey

[3] Inonu Univ, Sch Med, Turgut Ozal Med Ctr, Div Pediat Nephrol, Malatya, Turkey

来源：

ARCHIVES OF HELLENIC MEDICINE | 2020年 / 37卷 / 03期

关键词：

Factor VII deficiency; Pediatric renal transplantation; Recombinant factor VIIa; Renal transplantation; Thrombosis;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hemorrhagic complications in surgical patients with congenital factor VII deficiency are a major concern. Replacement therapy is required, in which recombinant factor VIIa is the first treatment choice, by virtue of its higher efficacy and no risk of infection. Because of the risk of vascular thrombosis, recombinant factor VIIa treatment may result in catastrophic outcomes, including graft loss in transplant patients. We present the case of a 7-year-old male who underwent renal transplantation and who developed renal thrombosis after recombinant factor VIIa substution therapy for factor VII deficiency.

引用

页码：391 / 394

页数：4

共 50 条

[1] Treatment of factor VII deficiency with recombinant factor VIIa
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[J]. HAEMOSTASIS, 1996, 26 : 155 - 158
[2] Recombinant factor VIIa prophylaxis in a patient with severe congenital factor VII deficiency
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[3] Factor VII deficiency in pregnancy treated with recombinant factor VIIa
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[5] Prophylactic effect of recombinant factor VIIa with congenital factor VII deficiency
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[6] Recombinant factor VIIa for patients with inhibitors to factor VIII or IX or factor VII deficiency
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[10] PERIPARTUM USE OF RECOMBINANT FACTOR VIIA IN INHERITED FACTOR-VII DEFICIENCY
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