Atypical Face Processing in Children With Tuberous Sclerosis Complex

被引：15

作者：

Jeste, Shafali Spurling ^{[1
,2
]}

Hirsch, Suzanna ^{[3
]}

Vogel-Farley, Vanessa ^{[3
]}

Norona, Amanda ^{[1
]}

Navalta, Mary-Clare ^{[1
]}

Gregas, Matt C. ^{[2
,4
]}

Prabhu, Sanjay P. ^{[5
]}

Sahin, Mustafa ^{[2
,6
]}

Nelson, Charles A. ^{[3
]}

机构：

[1] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USA

[2] Harvard Univ, Sch Med, Childrens Hosp, Dept Neurol, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Childrens Hosp, Labs Cognit Neurosci, Boston, MA 02115 USA

[4] Childrens Hosp, Clin Res Program, Boston, MA 02115 USA

[5] Harvard Univ, Sch Med, Childrens Hosp, Dept Neuroradiol, Boston, MA 02115 USA

[6] Childrens Hosp, FM Kirby Neurobiol Ctr, Boston, MA 02115 USA

来源：

JOURNAL OF CHILD NEUROLOGY | 2013年 / 28卷 / 12期

关键词：

tuberous sclerosis complex; autism; evoked potentials; cortical tubers; AUTISM SPECTRUM DISORDERS; EVENT-RELATED POTENTIALS; YOUNG-CHILDREN; TYPICAL DEVELOPMENT; BRAIN; RECOGNITION; ADOLESCENTS; IMPAIRMENT; ATTENTION; RESPONSES;

D O I：

10.1177/0883073812465122

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

There is a high incidence of autism in tuberous sclerosis complex. Given the evidence of impaired face processing in autism, the authors sought to investigate electrophysiological markers of face processing in children with tuberous sclerosis complex. The authors studied 19 children with tuberous sclerosis complex under age 4, and 20 age-matched controls, using a familiar-unfamiliar faces paradigm. Of the children, 6 with tuberous sclerosis complex (32%) had autism. Children with tuberous sclerosis complex showed a longer N290 latency than controls (276 ms vs 259 ms, P = .05) and also failed to show the expected hemispheric differences in face processing. The longest N290 latency was seen in (1) children with autism and tuberous sclerosis complex and (2) children with temporal lobe tubers. This study is the first to quantify atypical face processing in children with tuberous sclerosis complex. This functional impairment may provide insight into a mechanism underlying a pathway to autism in tuberous sclerosis complex.

引用

页码：1569 / 1576

页数：8

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