Structures of the double-ring AAA ATPase Pex1-Pex6 involved in peroxisome biogenesis

被引：17
|
作者：
Tan, Dongyan [1 ]
Blok, Neil B. [1 ,2 ]
Rapoport, Tom A. [1 ,2 ]
Walz, Thomas [3 ]
机构：
[1] Harvard Med Sch, Dept Cell Biol, 240 Longwood Ave, Boston, MA 02115 USA
[2] Harvard Med Sch, Howard Hughes Med Inst, Dept Cell Biol, Boston, MA 02115 USA
[3] Rockefeller Univ, 1230 York Ave, New York, NY 10065 USA
来源：
FEBS JOURNAL | 2016年 / 283卷 / 06期
基金：
美国国家卫生研究院;
关键词：
AAA ATPases; cryo-electron microscopy; peroxisome biogenesis; Pex1-Pex6; complex; single-particle analysis;
D O I：
10.1111/febs.13569
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Pex1 and Pex6 proteins are members of the AAA family of ATPases and are involved in peroxisome biogenesis. Recently, cryo-electron microscopy structures of the Pex1-Pex6 complex in different nucleotide states have been determined. This Structural Snapshot describes the structural features of the complex and their implications for its function, as well as questions that still await answers.
引用
收藏
页码：986 / 992
页数：7
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