Extracellular vesicles from tumor microenvironment transforms endothelial cell phenotype via downregulation of TRPV4 channels

被引：0
|
作者：
Guarino, Brianna [1 ]
Adapala, Ravi [1 ]
Kanugula, Anantha [1 ]
Dougherty, Julie [2 ]
Paruchuri, Sailaja [3 ]
Mahmood, Khan [2 ]
Thodeti, Charles [1 ]
机构：
[1] Northeast Ohio Med Univ, Rootstown, OH USA
[2] Ohio State Univ, Columbus, OH 43210 USA
[3] Univ Akron, Akron, OH 44325 USA
来源：
FASEB JOURNAL | 2020年 / 34卷
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1096/fasebj.2020.34.s1.05946
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页数：2
相关论文
共 47 条
  • [1] Extracellular Vesicles From Pathological Microenvironment Induce Endothelial Cell Transformation and Abnormal Angiogenesis via Modulation of TRPV4 Channels
    Guarino, Brianna D.
    Adapala, Ravi K.
    Kanugula, Anantha K.
    Lenkey, Nina M.
    Dougherty, Julie A.
    Paruchuri, Sailaja
    Khan, Mahmood
    Thodeti, Charles K.
    [J]. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2019, 7
  • [2] Modulation of Endothelial Cell Mitochondrial Phenotype and Angiogenesis by TRPV4
    Dalal, Kesha
    Katari, Venkatesh
    Kondapalli, Narendra
    Paruchuri, Sailala
    Thodeti, Charles
    [J]. PHYSIOLOGY, 2024, 39
  • [3] Tumor-Derived Extracellular Vesicles Induce Abnormal Angiogenesis via TRPV4 Downregulation and Subsequent Activation of YAP and VEGFR2
    Guarino, Brianna
    Katari, Venkatesh
    Adapala, Ravi
    Bhavnani, Neha
    Dougherty, Julie
    Khan, Mahmood
    Paruchuri, Sailaja
    Thodeti, Charles
    [J]. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2021, 9
  • [4] Endothelial TRPV4 channels prevent tumor growth and metastasis via modulation of tumor angiogenesis and vascular integrity
    Kanugula, Anantha K.
    Adapala, Ravi K.
    Jamaiyar, Anurag
    Lenkey, Nina
    Guarino, Brianna D.
    Liedtke, Wolfgang
    Yin, Liya
    Paruchuri, Sailaja
    Thodeti, Charles K.
    [J]. ANGIOGENESIS, 2021, 24 (03) : 647 - 656
  • [5] Endothelial TRPV4 channels prevent tumor growth and metastasis via modulation of tumor angiogenesis and vascular integrity
    Anantha K. Kanugula
    Ravi K. Adapala
    Anurag Jamaiyar
    Nina Lenkey
    Brianna D. Guarino
    Wolfgang Liedtke
    Liya Yin
    Sailaja Paruchuri
    Charles K. Thodeti
    [J]. Angiogenesis, 2021, 24 : 647 - 656
  • [6] Regulation of endothelial cell mitochondrial phenotype by mechanosensitive ion channel TRPV4
    Dalal, Kesha
    Katari, Venkatesh
    Paruchuri, Sailaja
    Thodeti, Charles
    [J]. PHYSIOLOGY, 2023, 38
  • [7] TRPV4 channels regulate tumor angiogenesis through the modulation of Rho-dependent tumor endothelial cell mechanosensitivity
    Thodeti, Charles K.
    Adapala, Ravi K.
    Ghosh, Kaustabh
    Thoppil, Roslin
    Dudley, Andrew C.
    Klagsbrun, Michael
    Chilian, William
    Ingber, Donald
    [J]. FASEB JOURNAL, 2012, 26
  • [8] TRPV4 Channels Regulate Tumor Angiogenesis via Modulation of ERK1/2-DependentTumor Endothelial Cell Proliferation
    Thoppil, Roslin
    Adapala, Ravi
    Cappelli, Holly
    Paruchuri, Sailaja
    Meszaros, J. Gary
    Thodeti, Charles
    [J]. FASEB JOURNAL, 2015, 29
  • [9] Tumor endothelial cell-derived extracellular vesicles contribute to tumor microenvironment remodeling
    Jian Gao
    Xiaodong Zhang
    Lei Jiang
    Yan Li
    Qianqian Zheng
    [J]. Cell Communication and Signaling, 20
  • [10] Tumor endothelial cell-derived extracellular vesicles contribute to tumor microenvironment remodeling
    Gao, Jian
    Zhang, Xiaodong
    Jiang, Lei
    Li, Yan
    Zheng, Qianqian
    [J]. CELL COMMUNICATION AND SIGNALING, 2022, 20 (01)
12345