Nitrite: A physiological store of nitric oxide and modulator of mitochondrial function

被引：144
|
作者：
Shiva, Sruti [1 ]
机构：
[1] Univ Pittsburgh, Dept Pharmacol & Chem Biol, Vasc Med Inst, Pittsburgh, PA 15261 USA
来源：
REDOX BIOLOGY | 2013年 / 1卷 / 01期
关键词：
Nitrite; Nitrate; Mitochondria; Hypoxia; VIVO ISCHEMIA-REPERFUSION; REVERSIBLE INHIBITION; RESPIRATORY-CHAIN; DIETARY NITRATE; C-OXIDASE; REDUCTASE; NO; SYNTHASE; MECHANISMS; GENERATION;
D O I：
10.1016/j.redox.2012.11.005
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nitrite, long considered a biologically inert metabolite of nitric oxide (NO) oxidation, is nosy accepted as a physiological storage pool of NO that can be reduced to bioactive NO in hypoxic conditions to mediate a spectrum of physiological responses in blood and tissue. This graphical review will provide a broad overview of the role of nitrite in physiology, focusing on its formation and reduction to NO as well as its regulation of the mitochondrion-an emerging subcellular target for its biological actions in tissues. (C) 2013 The Author. Published by Elsevier B.V.
引用
收藏
页码：40 / 44
页数：5
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