Protection of Dietary Polyphenols against Oral Cancer

被引:42
|
作者
Ding, Yijian [1 ]
Yao, Hua [1 ]
Yao, Yanan [1 ]
Fai, Leonard Yenwong [2 ]
Zhang, Zhuo [2 ]
机构
[1] Zhejiang Univ, Affiliated Hosp 1, Dept Stomatol, Hangzhou 310003, Zhejiang, Peoples R China
[2] Univ Kentucky, Grad Ctr Toxicol, Lexington, KY 40536 USA
基金
中国国家自然科学基金;
关键词
dietary polyphenols; tea polyphenols; (-)-epigallocatechin-3-gallate; oral cancer; cancer prevention; cancer therapy; cell death; cell growth; cell migration and invasion; SQUAMOUS-CELL CARCINOMA; BLACK TEA POLYPHENOLS; IN-VITRO CYTOTOXICITY; BUCCAL POUCH CARCINOGENESIS; GROWTH-FACTOR RECEPTOR; MAJOR FOOD SOURCES; GREEN TEA; EPIGALLOCATECHIN GALLATE; METABOLIZING-ENZYMES; SIGNALING PATHWAYS;
D O I
10.3390/nu5062173
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Oral cancer represents a health burden worldwide with approximate 275,000 new cases diagnosed annually. Its poor prognosis is due to local tumor invasion and frequent lymph node metastasis. Better understanding and development of novel treatments and chemo-preventive approaches for the preventive and therapeutic intervention of this type of cancer are necessary. Recent development of dietary polyphenols as cancer preventives and therapeutic agents is of great interest due to their antioxidant and anti-carcinogenic activities. Polyphenols may inhibit carcinogenesis in the stage of initiation, promotion, or progression. In particular, dietary polyphenols decrease incidence of carcinomas and exert protection against oral cancer by induction of cell death and inhibition of tumor growth, invasion, and metastasis. In this review, we discuss current progress of dietary polyphenols against oral cancers in vitro, in vivo, and at population levels.
引用
收藏
页码:2173 / 2191
页数:19
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