Synthesis, biopharmaceutical characterization, and antimicrobial study of novel azo dyes of 7-hydroxy-4-methylcoumarin

被引：12

作者：

Jogi, Pravin S. ^{[1
]}

Meshram, Jyotsana ^{[2
]}

Sheikh, Javed ^{[3
]}

Ben Hadda, Taibi ^{[4
]}

机构：

[1] Janata Mahavidyalaya, Chandrapur 442401, India

[2] RTM Nagpur Univ, Dept Chem, Nagpur 440033, Maharashtra, India

[3] Dhote Bandhu Sci Coll, Dept Chem, Gondia 441614, India

[4] Univ Mohammed 1, FSO, Lab Chim Mat, Oujda 60000, Morocco

来源：

MEDICINAL CHEMISTRY RESEARCH | 2013年 / 22卷 / 09期

关键词：

Bis-coumarins; Azo compounds; Antibacterial/antifungal activity; POM (Petra/Osiris/Molinspiration) analyses; COUMARIN;

D O I：

10.1007/s00044-012-0421-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Herein, we report the synthesis and biopharmaceutical characterization of coumarin based azo compounds. The novel coumarin based azo compounds were obtained by the coupling of bis-coumarin (2Z,2'Z)-2,2'-[ethane-1,2-diylbis(azan-1-yl-1-ylidene)]bis(4-methylchroman-7-ol) with diazotized aromatic amines. The compounds were fully characterized using spectroscopic analytical method and tested for their antibacterial and antifungal activity. A correlation of structure and activities relationship of these compounds with respect to molecular modeling, Lipinski rule of five, drug-likeness, toxicity profiles, and other physico-chemical properties of drugs are described and verified experimentally.

引用

页码：4202 / 4210

页数：9

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