Genotoxic and anti-genotoxic effects of esculin and its oligomer fractions against mitomycin C-induced DNA damages in mice

被引：16
|
作者：
Bzeouich, Imen Mokdad [1 ,2 ]
Mustapha, Nadia [1 ,2 ]
Maatouk, Mouna [1 ,2 ]
Ghedira, Kamel [1 ]
Ghoul, Mohamed [3 ]
Chekir-Ghedira, Leila [2 ]
机构：
[1] Univ Monastir, Fac Med Dent, Lab Cellular & Mol Biol, Avicenna St, Monastir 5000, Tunisia
[2] Univ Monastir, Fac Pharm, Unit Bioact & Nat Subst & Biotechnol UR12ES12, Avicenna St, Monastir 5000, Tunisia
[3] Natl Polytech Inst Lorraine ENSAIA INPL, Natl Sch Agron & Food Ind, Lab Biomol Engn, F-54505 Vandoeuvre Les Nancy, France
来源：
REGULATORY TOXICOLOGY AND PHARMACOLOGY | 2016年 / 82卷
关键词：
Esculin; Oligomer fractions; Mitomycin C; Antigenotoxicity; Lipid peroxidation; BONE-MARROW-CELLS; COUMARIN; ACID;
D O I：
10.1016/j.yrtph.2016.11.002
中图分类号：
DF [法律]; D9 [法律]; R [医药、卫生];
学科分类号：
0301 ; 10 ;
摘要：
Mitomycin C is one of the most effective chemotherapeutic drugs against various solid tumors. However, despite its wide spectrum of clinical benefits, this agent is capable of inducing various types of genotoxicity. In this study, we investigated the effect of esculin and its oligomer fractions (E1, E2 and E3) against mitomycin C induced genotoxicity in liver and kidney cells isolated from Balb/C mice using the comet assay. Esculin and its oligomer fractions were not genotoxic at the tested doses (20 mg/kg and 40 mg/kg b.w). A significant decrease in DNA damages was observed, suggesting a protective role of esculin and its oligomer fractions against the genotoxicity induced by mitomycin C on liver and kidney cells. Moreover, esculin and its oligomer fractions did not induce an increase of malondialdehyde levels. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码：48 / 52
页数：5
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