Integrated fluorescence correlation spectroscopy device for point-of-care clinical applications

被引：3
|
作者：
Olson, Eben [1 ]
Torres, Richard [2 ]
Levene, Michael J. [1 ]
机构：
[1] Yale Univ, Sch Engn & Appl Sci, Dept Biomed Engn, New Haven, CT 06510 USA
[2] Yale Univ, Sch Med, Dept Lab Med, New Haven, CT 06510 USA
来源：
BIOMEDICAL OPTICS EXPRESS | 2013年 / 4卷 / 07期
关键词：
LENS;
D O I：
10.1364/BOE.4.001074
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
We describe an optical system which reduces the cost and complexity of fluorescence correlation spectroscopy (FCS), intended to increase the suitability of the technique for clinical use. Integration of the focusing optics and sample chamber into a plastic component produces a design which is simple to align and operate. We validate the system by measurements on fluorescent dye, and compare the results to a commercial instrument. In addition, we demonstrate its application to measurements of concentration and multimerization of the clinically relevant protein von Willebrand factor (vWF) in human plasma. (C) 2013 Optical Society of America
引用
收藏
页码：1074 / 1082
页数：9
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